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Comparative assessment of strategies to identify similar ligand-binding pockets in proteins
BACKGROUND: Detecting similar ligand-binding sites in globally unrelated proteins has a wide range of applications in modern drug discovery, including drug repurposing, the prediction of side effects, and drug-target interactions. Although a number of techniques to compare binding pockets have been...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845264/ https://www.ncbi.nlm.nih.gov/pubmed/29523085 http://dx.doi.org/10.1186/s12859-018-2109-2 |