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Testosterone and androstanediol glucuronide among men in NHANES III

BACKGROUND: Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown. We hence examined the association between testosterone and...

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Autores principales: Duan, Chuan Wei, Xu, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845266/
https://www.ncbi.nlm.nih.gov/pubmed/29523115
http://dx.doi.org/10.1186/s12889-018-5255-6
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author Duan, Chuan Wei
Xu, Lin
author_facet Duan, Chuan Wei
Xu, Lin
author_sort Duan, Chuan Wei
collection PubMed
description BACKGROUND: Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown. We hence examined the association between testosterone and androstanediol glucuronide (AG), a reliable measure of androgen activity, in a nationally representative sample of US men. METHODS: Cross-sectional analysis was based on 1493 men from the Third National Health and Nutrition examination Survey (NHANES III) conducted from 1988 to 1991. Serum testosterone and AG were measured by immunoassay. Kernel density was used to estimate the average density of serum AG concentrations by quartiles of testosterone. RESULTS: Testosterone was weakly and positively correlated with AG (correlation coefficient = 0.18). The kernel density estimates show that the distributions are quite similar between the quartiles of testosterone. After adjustment for age, the distributions of AG in quartiles of testosterone did not change. The correlation between testosterone and AG was stronger in men with younger age, lower body mass index, non-smoking and good self-rated health and health status. CONCLUSIONS: Serum testosterone is weakly correlated with total androgen activities, and the correlation is even weaker for those with poor self-rated health. Our results suggest that measurement of total androgen activity in addition to testosterone is necessary in clinical practice, especially before administration of androgen replacement therapy.
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spelling pubmed-58452662018-03-19 Testosterone and androstanediol glucuronide among men in NHANES III Duan, Chuan Wei Xu, Lin BMC Public Health Research Article BACKGROUND: Most of the androgen replacement therapies were based on serum testosterone and without measurements of total androgen activities. Whether those with low testosterone also have low levels of androgen activity is largely unknown. We hence examined the association between testosterone and androstanediol glucuronide (AG), a reliable measure of androgen activity, in a nationally representative sample of US men. METHODS: Cross-sectional analysis was based on 1493 men from the Third National Health and Nutrition examination Survey (NHANES III) conducted from 1988 to 1991. Serum testosterone and AG were measured by immunoassay. Kernel density was used to estimate the average density of serum AG concentrations by quartiles of testosterone. RESULTS: Testosterone was weakly and positively correlated with AG (correlation coefficient = 0.18). The kernel density estimates show that the distributions are quite similar between the quartiles of testosterone. After adjustment for age, the distributions of AG in quartiles of testosterone did not change. The correlation between testosterone and AG was stronger in men with younger age, lower body mass index, non-smoking and good self-rated health and health status. CONCLUSIONS: Serum testosterone is weakly correlated with total androgen activities, and the correlation is even weaker for those with poor self-rated health. Our results suggest that measurement of total androgen activity in addition to testosterone is necessary in clinical practice, especially before administration of androgen replacement therapy. BioMed Central 2018-03-09 /pmc/articles/PMC5845266/ /pubmed/29523115 http://dx.doi.org/10.1186/s12889-018-5255-6 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Duan, Chuan Wei
Xu, Lin
Testosterone and androstanediol glucuronide among men in NHANES III
title Testosterone and androstanediol glucuronide among men in NHANES III
title_full Testosterone and androstanediol glucuronide among men in NHANES III
title_fullStr Testosterone and androstanediol glucuronide among men in NHANES III
title_full_unstemmed Testosterone and androstanediol glucuronide among men in NHANES III
title_short Testosterone and androstanediol glucuronide among men in NHANES III
title_sort testosterone and androstanediol glucuronide among men in nhanes iii
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845266/
https://www.ncbi.nlm.nih.gov/pubmed/29523115
http://dx.doi.org/10.1186/s12889-018-5255-6
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