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Epigenetic regulation of cancer progression by EZH2: from biological insights to therapeutic potential

Enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a catalytic component of PRC2, catalyzes tri-methylation of histone H3 at Lys 27 (H3K27me3) to regulate gene expression through epigenetic machinery. EZH2 also functions both as a transcriptional suppressor and a transcriptional co-...

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Detalles Bibliográficos
Autores principales:	Gan, Lu, Yang, Yanan, Li, Qian, Feng, Yi, Liu, Tianshu, Guo, Weijian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845366/ https://www.ncbi.nlm.nih.gov/pubmed/29556394 http://dx.doi.org/10.1186/s40364-018-0122-2

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