Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis

Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells are an attractive therapeutic option. Mesenchymal stem cells (MSCs) especially show promise a...

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Detalles Bibliográficos
Autores principales: Zhang, Yongting, Li, Yuwen, Zhang, Lili, Li, Jun, Zhu, Chuanlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845383/
https://www.ncbi.nlm.nih.gov/pubmed/29523186
http://dx.doi.org/10.1186/s13287-018-0814-4
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author Zhang, Yongting
Li, Yuwen
Zhang, Lili
Li, Jun
Zhu, Chuanlong
author_facet Zhang, Yongting
Li, Yuwen
Zhang, Lili
Li, Jun
Zhu, Chuanlong
author_sort Zhang, Yongting
collection PubMed
description Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells are an attractive therapeutic option. Mesenchymal stem cells (MSCs) especially show promise as an alternative treatment for hepatic cirrhosis in animal models and during clinical trials. Nevertheless, the homing of transplanted MSCs to the liver occurs in limited numbers. Therefore, we review the strategies for enhancing the homing of MSCs, mainly via the delivery routes, optimizing cell culture conditions, stimulating the target sites, and genetic modification.
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spelling pubmed-58453832018-03-19 Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis Zhang, Yongting Li, Yuwen Zhang, Lili Li, Jun Zhu, Chuanlong Stem Cell Res Ther Review Nowadays, orthotopic liver transplantation is considered the most efficient approach to the end stage of chronic hepatic cirrhosis. Because of the limitations of orthotopic liver transplantation, stem cells are an attractive therapeutic option. Mesenchymal stem cells (MSCs) especially show promise as an alternative treatment for hepatic cirrhosis in animal models and during clinical trials. Nevertheless, the homing of transplanted MSCs to the liver occurs in limited numbers. Therefore, we review the strategies for enhancing the homing of MSCs, mainly via the delivery routes, optimizing cell culture conditions, stimulating the target sites, and genetic modification. BioMed Central 2018-03-09 /pmc/articles/PMC5845383/ /pubmed/29523186 http://dx.doi.org/10.1186/s13287-018-0814-4 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Zhang, Yongting
Li, Yuwen
Zhang, Lili
Li, Jun
Zhu, Chuanlong
Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
title Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
title_full Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
title_fullStr Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
title_full_unstemmed Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
title_short Mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
title_sort mesenchymal stem cells: potential application for the treatment of hepatic cirrhosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845383/
https://www.ncbi.nlm.nih.gov/pubmed/29523186
http://dx.doi.org/10.1186/s13287-018-0814-4
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AT zhanglili mesenchymalstemcellspotentialapplicationforthetreatmentofhepaticcirrhosis
AT lijun mesenchymalstemcellspotentialapplicationforthetreatmentofhepaticcirrhosis
AT zhuchuanlong mesenchymalstemcellspotentialapplicationforthetreatmentofhepaticcirrhosis

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