Cargando…

Cardiac-Specific Deletion of Pyruvate Dehydrogenase Impairs Glucose Oxidation Rates and Induces Diastolic Dysfunction

Obesity and type 2 diabetes (T2D) increase the risk for cardiomyopathy, which is the presence of ventricular dysfunction in the absence of underlying coronary artery disease and/or hypertension. As myocardial energy metabolism is altered during obesity/T2D (increased fatty acid oxidation and decreas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gopal, Keshav, Almutairi, Malak, Al Batran, Rami, Eaton, Farah, Gandhi, Manoj, Ussher, John Reyes
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Cardiovascular Medicine
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845646/ https://www.ncbi.nlm.nih.gov/pubmed/29560354 http://dx.doi.org/10.3389/fcvm.2018.00017

Ejemplares similares

Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome
por: Greenwell, Amanda A., et al.
Publicado: (2022)

The Impact of Antidiabetic Therapies on Diastolic Dysfunction and Diabetic Cardiomyopathy
por: Gopal, Keshav, et al.
Publicado: (2020)

Pyruvate Dehydrogenase Complex and Glucose Oxidation as a Therapeutic Target in Diabetic Heart Disease
por: Tabatabaei Dakhili, Seyed Amirhossein, et al.
Publicado: (2023)

Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis
por: Gopal, Keshav, et al.
Publicado: (2023)

Cardiovascular Biomarkers and Diastolic Dysfunction in Patients With Chronic Chagas Cardiomyopathy
por: Echeverría, Luis E., et al.
Publicado: (2021)

Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
por: Jeoung, Nam Ho, et al.
Publicado: (2010)

Isoproterenol-Induced Cardiac Diastolic Dysfunction in Mice: A Systems Genetics Analysis
por: Wang, Jessica, et al.
Publicado: (2019)

Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
por: Park, Sungmi, et al.
Publicado: (2018)

In Silico Analysis of Differential Gene Expression in Three Common Rat Models of Diastolic Dysfunction
por: Altara, Raffaele, et al.
Publicado: (2018)

Role of pyruvate dehydrogenase complex in traumatic brain injury and Measurement of pyruvate dehydrogenase enzyme by dipstick test
por: Sharma, Pushpa, et al.
Publicado: (2009)

Lactate Dehydrogenase B and Pyruvate Oxidation Pathway Associated With Carfilzomib-Related Cardiotoxicity in Multiple Myeloma Patients: Result of a Multi-Omics Integrative Analysis
por: Tantawy, Marwa, et al.
Publicado: (2021)

Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions
por: Amirrad, Farideh, et al.
Publicado: (2021)

Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study
por: Daka, Bledar, et al.
Publicado: (2023)

Hyperinsulinemia and sulfonylurea use are independently associated with left ventricular diastolic dysfunction in patients with type 2 diabetes mellitus with suboptimal blood glucose control
por: Inoue, Tomoaki, et al.
Publicado: (2016)

Effects of arsenic on pyruvate dehydrogenase activation.
por: Schiller, C M, et al.
Publicado: (1977)

Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
por: Jeong, Ji Yun, et al.
Publicado: (2012)

Pyruvate dehydrogenase levels are low in sepsis
por: Nuzzo, E, et al.
Publicado: (2015)

Regulation of hepatic pyruvate dehydrogenase phosphorylation in offspring glucose intolerance induced by intrauterine hyperglycemia
por: Zhang, Yong, et al.
Publicado: (2017)

Left ventricular hypertrophy, diastolic dysfunction and right ventricular load predict outcome in moderate aortic stenosis
por: Stöbe, Stephan, et al.
Publicado: (2023)

South Asian-Specific MYBPC3(Δ25bp) Deletion Carriers Display Hypercontraction and Impaired Diastolic Function Under Exercise Stress
por: Bazrafshan, Sholeh, et al.
Publicado: (2021)

Topoisomerase 2B Decrease Results in Diastolic Dysfunction via p53 and Akt: A Novel Pathway
por: Moudgil, Rohit, et al.
Publicado: (2020)

DeepStrain Evidence of Asymptomatic Left Ventricular Diastolic and Systolic Dysfunction in Young Adults With Cardiac Risk Factors
por: Morales, Manuel A., et al.
Publicado: (2022)

Electrocardiographic Features of Left Ventricular Diastolic Dysfunction and Heart Failure With Preserved Ejection Fraction: A Systematic Review
por: Van Ommen, Anne-Mar, et al.
Publicado: (2021)

Electrocardiographic and cardiometabolic risk markers of left ventricular diastolic dysfunction in physically active adults: CHIEF heart study
por: Liu, Pang-Yen, et al.
Publicado: (2022)

Left Ventricular Diastolic Dysfunction Is Not Associated With Pulmonary Edema in Septic Patients. A Prospective Observational Cohort Study
por: Kahl, Ursula, et al.
Publicado: (2022)

The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
por: Lee, In-Kyu
Publicado: (2014)

Phenylbutyrate increases activity of pyruvate dehydrogenase complex
por: Ferriero, Rosa, et al.
Publicado: (2013)

Systolic [Ca(2+)](i) regulates diastolic levels in rat ventricular myocytes
por: Sankaranarayanan, Rajiv, et al.
Publicado: (2017)

Circulating microRNA-133a in Patients With Arterial Hypertension, Hypertensive Heart Disease, and Left Ventricular Diastolic Dysfunction
por: Koval, Sergiy M., et al.
Publicado: (2020)

Prognostic Value of Diastolic Dysfunction Derived From D-SPECT in Coronary Artery Disease Patients With Normal Ejection Fraction
por: Xu, Bin, et al.
Publicado: (2021)

High Neutrophil to Lymphocyte Ratio and Its Gene Signatures Correlate With Diastolic Dysfunction in Heart Failure With Preserved Ejection Fraction
por: Bai, Bo, et al.
Publicado: (2021)

Asp295 Stabilizes the Active-Site Loop Structure of Pyruvate Dehydrogenase, Facilitating Phosphorylation of Ser292 by Pyruvate Dehydrogenase-Kinase
por: Hirani, Tripty A., et al.
Publicado: (2011)

The Link between Mitochondrial Dysfunction and Sarcopenia: An Update Focusing on the Role of Pyruvate Dehydrogenase Kinase 4
por: Kim, Min-Ji, et al.
Publicado: (2023)

Pyruvate dehydrogenase complex and lactate dehydrogenase are targets for therapy of acute liver failure
por: Ferriero, Rosa, et al.
Publicado: (2018)

A novel null mutation in the pyruvate dehydrogenase phosphatase catalytic subunit gene (PDP1) causing pyruvate dehydrogenase complex deficiency
por: Bedoyan, Jirair K., et al.
Publicado: (2019)

Assessment of Diastolic Function in Congenital Heart Disease
por: Panesar, Dilveer Kaur, et al.
Publicado: (2017)

End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium
por: Najafi, Aref, et al.
Publicado: (2019)

Prevalence and Predictors of Left Ventricular Diastolic Dysfunction in Malaysian Patients With Type 2 Diabetes Mellitus Without Prior Known Cardiovascular Disease
por: Chee, Kok Han, et al.
Publicado: (2021)

The effects of cardiac structure, valvular regurgitation, and left ventricular diastolic dysfunction on the diagnostic accuracy of Murray law–based quantitative flow ratio
por: Yang, Junqing, et al.
Publicado: (2023)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis
por: Ferrarini, Mariana Galvão, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qog0tssmbadbish1d85t99e1i6