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Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia

As is known, hypoxia leads to an increase in microcirculatory blood flow of the skin in healthy volunteers. In this pilot study, we investigated microcirculatory blood flow and reactive hyperemia of the skin in healthy subjects in normobaric hypoxia. Furthermore, we examined differences in microcirc...

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Autores principales: Treml, Benedikt, Kleinsasser, Axel, Stadlbauer, Karl-Heinz, Steiner, Iris, Pajk, Werner, Pilch, Michael, Burtscher, Martin, Knotzer, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845666/
https://www.ncbi.nlm.nih.gov/pubmed/29559919
http://dx.doi.org/10.3389/fphys.2018.00160
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author Treml, Benedikt
Kleinsasser, Axel
Stadlbauer, Karl-Heinz
Steiner, Iris
Pajk, Werner
Pilch, Michael
Burtscher, Martin
Knotzer, Hans
author_facet Treml, Benedikt
Kleinsasser, Axel
Stadlbauer, Karl-Heinz
Steiner, Iris
Pajk, Werner
Pilch, Michael
Burtscher, Martin
Knotzer, Hans
author_sort Treml, Benedikt
collection PubMed
description As is known, hypoxia leads to an increase in microcirculatory blood flow of the skin in healthy volunteers. In this pilot study, we investigated microcirculatory blood flow and reactive hyperemia of the skin in healthy subjects in normobaric hypoxia. Furthermore, we examined differences in microcirculation between hypoxic subjects with and without short-term acclimatization, whether or not skin microvasculature can acclimatize. Fourty-six healthy persons were randomly allocated to either short-term acclimatization using intermittent hypoxia for 1 h over 7 days at an FiO(2) 0.126 (treatment, n = 23) or sham short-term acclimatization for 1 h over 7 days at an FiO(2) 0.209 (control, n = 23). Measurements were taken in normoxia and at 360 and 720 min during hypoxia (FiO(2) 0.126). Microcirculatory cutaneous blood flow was assessed with a laser Doppler flowmeter on the forearm. Reactive hyperemia was induced by an ischemic stimulus. Measurements included furthermore hemodynamics, blood gas analyses and blood lactate. Microcirculatory blood flow increased progressively during hypoxia (12.3 ± 7.1–19.0 ± 8.1 perfusion units; p = 0.0002) in all subjects. The magnitude of the reactive hyperemia was diminished during hypoxia (58.2 ± 14.5–40.3 ± 27.4 perfusion units; p = 0.0003). Short-term acclimatization had no effect on microcirculatory blood flow. When testing for a hyperemic response of the skin's microcirculation we found a diminished signal in hypoxia, indicative for a compromised auto-regulative circulatory capacity. Furthermore, hypoxic short-term acclimatization did not affect cutaneous microcirculatory blood flow. Seemingly, circulation of the skin was unable to acclimatize using a week-long short-term acclimatization protocol. A potential limitation of our study may be the 7 days between acclimatization and the experimental test run. However, there is evidence that the hypoxic ventilatory response, an indicator of acclimatization, is increased for 1 week after short-term acclimatization. Then again, 1 week is what one needs to get from home to a location at significant altitude.
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spelling pubmed-58456662018-03-20 Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia Treml, Benedikt Kleinsasser, Axel Stadlbauer, Karl-Heinz Steiner, Iris Pajk, Werner Pilch, Michael Burtscher, Martin Knotzer, Hans Front Physiol Physiology As is known, hypoxia leads to an increase in microcirculatory blood flow of the skin in healthy volunteers. In this pilot study, we investigated microcirculatory blood flow and reactive hyperemia of the skin in healthy subjects in normobaric hypoxia. Furthermore, we examined differences in microcirculation between hypoxic subjects with and without short-term acclimatization, whether or not skin microvasculature can acclimatize. Fourty-six healthy persons were randomly allocated to either short-term acclimatization using intermittent hypoxia for 1 h over 7 days at an FiO(2) 0.126 (treatment, n = 23) or sham short-term acclimatization for 1 h over 7 days at an FiO(2) 0.209 (control, n = 23). Measurements were taken in normoxia and at 360 and 720 min during hypoxia (FiO(2) 0.126). Microcirculatory cutaneous blood flow was assessed with a laser Doppler flowmeter on the forearm. Reactive hyperemia was induced by an ischemic stimulus. Measurements included furthermore hemodynamics, blood gas analyses and blood lactate. Microcirculatory blood flow increased progressively during hypoxia (12.3 ± 7.1–19.0 ± 8.1 perfusion units; p = 0.0002) in all subjects. The magnitude of the reactive hyperemia was diminished during hypoxia (58.2 ± 14.5–40.3 ± 27.4 perfusion units; p = 0.0003). Short-term acclimatization had no effect on microcirculatory blood flow. When testing for a hyperemic response of the skin's microcirculation we found a diminished signal in hypoxia, indicative for a compromised auto-regulative circulatory capacity. Furthermore, hypoxic short-term acclimatization did not affect cutaneous microcirculatory blood flow. Seemingly, circulation of the skin was unable to acclimatize using a week-long short-term acclimatization protocol. A potential limitation of our study may be the 7 days between acclimatization and the experimental test run. However, there is evidence that the hypoxic ventilatory response, an indicator of acclimatization, is increased for 1 week after short-term acclimatization. Then again, 1 week is what one needs to get from home to a location at significant altitude. Frontiers Media S.A. 2018-03-06 /pmc/articles/PMC5845666/ /pubmed/29559919 http://dx.doi.org/10.3389/fphys.2018.00160 Text en Copyright © 2018 Treml, Kleinsasser, Stadlbauer, Steiner, Pajk, Pilch, Burtscher and Knotzer. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Treml, Benedikt
Kleinsasser, Axel
Stadlbauer, Karl-Heinz
Steiner, Iris
Pajk, Werner
Pilch, Michael
Burtscher, Martin
Knotzer, Hans
Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia
title Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia
title_full Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia
title_fullStr Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia
title_full_unstemmed Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia
title_short Cutaneous Microvascular Blood Flow and Reactivity in Hypoxia
title_sort cutaneous microvascular blood flow and reactivity in hypoxia
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845666/
https://www.ncbi.nlm.nih.gov/pubmed/29559919
http://dx.doi.org/10.3389/fphys.2018.00160
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