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Vaccinia virus protein A49 activates Wnt signalling by targetting the E3 ligase β-TrCP

Vaccinia virus (VACV) encodes multiple proteins inhibiting the NF-κB signalling pathway. One of these, A49, targets the E3 ubiquitin ligase β-TrCP, which is responsible for the ubiquitylation and consequential proteosomal degradation of IκBα and the release of the NF-κB heterodimer. β-TrCP is a plei...

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Detalles Bibliográficos
Autores principales:	Maluquer de Motes, Carlos, Smith, Geoffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2017
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845699/ https://www.ncbi.nlm.nih.gov/pubmed/29058646 http://dx.doi.org/10.1099/jgv.0.000946

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