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Non-additive Effects in Genomic Selection

In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism) markers used to calculate the p...

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Autores principales: Varona, Luis, Legarra, Andres, Toro, Miguel A., Vitezica, Zulma G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845743/
https://www.ncbi.nlm.nih.gov/pubmed/29559995
http://dx.doi.org/10.3389/fgene.2018.00078
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author Varona, Luis
Legarra, Andres
Toro, Miguel A.
Vitezica, Zulma G.
author_facet Varona, Luis
Legarra, Andres
Toro, Miguel A.
Vitezica, Zulma G.
author_sort Varona, Luis
collection PubMed
description In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism) markers used to calculate the prediction of the breeding values of candidates for selection. Nevertheless, the availability of estimates of non-additive effects is of interest because: (i) they contribute to an increase in the accuracy of the prediction of breeding values and the genetic response; (ii) they allow the definition of mate allocation procedures between candidates for selection; and (iii) they can be used to enhance non-additive genetic variation through the definition of appropriate crossbreeding or purebred breeding schemes. This study presents a review of methods for the incorporation of non-additive genetic effects into genomic selection procedures and their potential applications in the prediction of future performance, mate allocation, crossbreeding, and purebred selection. The work concludes with a brief outline of some ideas for future lines of that may help the standard inclusion of non-additive effects in genomic selection.
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spelling pubmed-58457432018-03-20 Non-additive Effects in Genomic Selection Varona, Luis Legarra, Andres Toro, Miguel A. Vitezica, Zulma G. Front Genet Genetics In the last decade, genomic selection has become a standard in the genetic evaluation of livestock populations. However, most procedures for the implementation of genomic selection only consider the additive effects associated with SNP (Single Nucleotide Polymorphism) markers used to calculate the prediction of the breeding values of candidates for selection. Nevertheless, the availability of estimates of non-additive effects is of interest because: (i) they contribute to an increase in the accuracy of the prediction of breeding values and the genetic response; (ii) they allow the definition of mate allocation procedures between candidates for selection; and (iii) they can be used to enhance non-additive genetic variation through the definition of appropriate crossbreeding or purebred breeding schemes. This study presents a review of methods for the incorporation of non-additive genetic effects into genomic selection procedures and their potential applications in the prediction of future performance, mate allocation, crossbreeding, and purebred selection. The work concludes with a brief outline of some ideas for future lines of that may help the standard inclusion of non-additive effects in genomic selection. Frontiers Media S.A. 2018-03-06 /pmc/articles/PMC5845743/ /pubmed/29559995 http://dx.doi.org/10.3389/fgene.2018.00078 Text en Copyright © 2018 Varona, Legarra, Toro and Vitezica. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Varona, Luis
Legarra, Andres
Toro, Miguel A.
Vitezica, Zulma G.
Non-additive Effects in Genomic Selection
title Non-additive Effects in Genomic Selection
title_full Non-additive Effects in Genomic Selection
title_fullStr Non-additive Effects in Genomic Selection
title_full_unstemmed Non-additive Effects in Genomic Selection
title_short Non-additive Effects in Genomic Selection
title_sort non-additive effects in genomic selection
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845743/
https://www.ncbi.nlm.nih.gov/pubmed/29559995
http://dx.doi.org/10.3389/fgene.2018.00078
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