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Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy

BACKGROUND: Bilateral vestibulopathy (BVP) is a debilitating disorder characterized by the hypofunction of both vestibular end organs or nerves. The most frequent identifiable causes of BVP are ototoxic drug effects, infectious and autoimmune disorders. However, the majority of cases remain idiopath...

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Autor principal: Gürkov, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845752/
https://www.ncbi.nlm.nih.gov/pubmed/29559948
http://dx.doi.org/10.3389/fneur.2018.00119
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author Gürkov, Robert
author_facet Gürkov, Robert
author_sort Gürkov, Robert
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description BACKGROUND: Bilateral vestibulopathy (BVP) is a debilitating disorder characterized by the hypofunction of both vestibular end organs or nerves. The most frequent identifiable causes of BVP are ototoxic drug effects, infectious and autoimmune disorders. However, the majority of cases remain idiopathic. Very recently, the first discovery of a clinical case of Amiodarone-associated BVP has been reported. METHODS: An overview of the literature concerning the relation between amiodarone toxicity and BVP is presented and discussed. RESULTS: Older reports on amiodarone-induced symptoms of vertigo and gait instability lack a description of vestibular function test results. Recent evidence from retrospective studies including vestibular function testing in patients taking amiodarone have identified the drug as the hitherto unsuspected potential cause of a relatively large proportion of cases with “idiopathic” BVP. CONCLUSION: Patients who receive amiodarone should be monitored with vestibular function testing in order to recognize potential adverse effects on the vestibular system and allow for an informed decision on possible drug reduction or withdrawal.
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spelling pubmed-58457522018-03-20 Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy Gürkov, Robert Front Neurol Neuroscience BACKGROUND: Bilateral vestibulopathy (BVP) is a debilitating disorder characterized by the hypofunction of both vestibular end organs or nerves. The most frequent identifiable causes of BVP are ototoxic drug effects, infectious and autoimmune disorders. However, the majority of cases remain idiopathic. Very recently, the first discovery of a clinical case of Amiodarone-associated BVP has been reported. METHODS: An overview of the literature concerning the relation between amiodarone toxicity and BVP is presented and discussed. RESULTS: Older reports on amiodarone-induced symptoms of vertigo and gait instability lack a description of vestibular function test results. Recent evidence from retrospective studies including vestibular function testing in patients taking amiodarone have identified the drug as the hitherto unsuspected potential cause of a relatively large proportion of cases with “idiopathic” BVP. CONCLUSION: Patients who receive amiodarone should be monitored with vestibular function testing in order to recognize potential adverse effects on the vestibular system and allow for an informed decision on possible drug reduction or withdrawal. Frontiers Media S.A. 2018-03-06 /pmc/articles/PMC5845752/ /pubmed/29559948 http://dx.doi.org/10.3389/fneur.2018.00119 Text en Copyright © 2018 Gürkov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Gürkov, Robert
Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy
title Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy
title_full Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy
title_fullStr Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy
title_full_unstemmed Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy
title_short Amiodarone: A Newly Discovered Association with Bilateral Vestibulopathy
title_sort amiodarone: a newly discovered association with bilateral vestibulopathy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845752/
https://www.ncbi.nlm.nih.gov/pubmed/29559948
http://dx.doi.org/10.3389/fneur.2018.00119
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