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Exhaustion of the CD8(+) T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta

Pathogenic gain-of-function mutations in the gene encoding phosphoinositide 3-kinase delta (PI3Kδ) cause activated PI3Kδ syndrome (APDS), a disease characterized by humoral immunodeficiency, lymphadenopathy, and an inability to control persistent viral infections including Epstein–Barr virus (EBV) a...

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Detalles Bibliográficos
Autores principales:	Wentink, Marjolein W. J., Mueller, Yvonne M., Dalm, Virgil A. S. H., Driessen, Gertjan J., van Hagen, P. Martin, van Montfrans, Joris M., van der Burg, Mirjam, Katsikis, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5845988/ https://www.ncbi.nlm.nih.gov/pubmed/29563914 http://dx.doi.org/10.3389/fimmu.2018.00446

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