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Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception

[Image: see text] Na,K-ATPase α4 is a testis-specific plasma membrane Na(+) and K(+) transporter expressed in sperm flagellum. Deletion of Na,K-ATPase α4 in male mice results in complete infertility, making it an attractive target for male contraception. Na,K-ATPase α4 is characterized by a high aff...

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Detalles Bibliográficos
Autores principales:	Syeda, Shameem Sultana, Sánchez, Gladis, Hong, Kwon Ho, Hawkinson, Jon E., Georg, Gunda I., Blanco, Gustavo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846083/ https://www.ncbi.nlm.nih.gov/pubmed/29291372 http://dx.doi.org/10.1021/acs.jmedchem.7b00925

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