Granulomatous Response in Intracranial Germinomas: Diagnostic Problems

Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. In rare cases, the granulomatous component may obscure the tumor proper and lead to diagnostic difficulties/dile...

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Autores principales: Jinkala, Sree Rekha, Muthalagan, Elancheran, Badhe, Bhawana Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846222/
https://www.ncbi.nlm.nih.gov/pubmed/29552538
http://dx.doi.org/10.4103/ijabmr.IJABMR_157_17
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author Jinkala, Sree Rekha
Muthalagan, Elancheran
Badhe, Bhawana Ashok
author_facet Jinkala, Sree Rekha
Muthalagan, Elancheran
Badhe, Bhawana Ashok
author_sort Jinkala, Sree Rekha
collection PubMed
description Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. In rare cases, the granulomatous component may obscure the tumor proper and lead to diagnostic difficulties/dilemmas. We report a case of suprasellar germinoma in a 17-year-old boy which showed granulomatous response. We discuss the differentials to be considered in such a scenario and discuss the utility of squash cytology and immunohistochemistry in these lesions.
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spelling pubmed-58462222018-03-16 Granulomatous Response in Intracranial Germinomas: Diagnostic Problems Jinkala, Sree Rekha Muthalagan, Elancheran Badhe, Bhawana Ashok Int J Appl Basic Med Res Case Report Intracranial germinomas are rare and account for <0.5% of primary intracranial tumors. In contrast to the gonadal germinomas, these do not show granulomatous response within the tumor. In rare cases, the granulomatous component may obscure the tumor proper and lead to diagnostic difficulties/dilemmas. We report a case of suprasellar germinoma in a 17-year-old boy which showed granulomatous response. We discuss the differentials to be considered in such a scenario and discuss the utility of squash cytology and immunohistochemistry in these lesions. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5846222/ /pubmed/29552538 http://dx.doi.org/10.4103/ijabmr.IJABMR_157_17 Text en Copyright: © 2018 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Jinkala, Sree Rekha
Muthalagan, Elancheran
Badhe, Bhawana Ashok
Granulomatous Response in Intracranial Germinomas: Diagnostic Problems
title Granulomatous Response in Intracranial Germinomas: Diagnostic Problems
title_full Granulomatous Response in Intracranial Germinomas: Diagnostic Problems
title_fullStr Granulomatous Response in Intracranial Germinomas: Diagnostic Problems
title_full_unstemmed Granulomatous Response in Intracranial Germinomas: Diagnostic Problems
title_short Granulomatous Response in Intracranial Germinomas: Diagnostic Problems
title_sort granulomatous response in intracranial germinomas: diagnostic problems
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846222/
https://www.ncbi.nlm.nih.gov/pubmed/29552538
http://dx.doi.org/10.4103/ijabmr.IJABMR_157_17
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