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Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Appro...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846224/ https://www.ncbi.nlm.nih.gov/pubmed/29552540 http://dx.doi.org/10.4103/ijabmr.IJABMR_402_16 |
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author | Raju, Kalyani Venkataramappa, Srinivas Murthy |
author_facet | Raju, Kalyani Venkataramappa, Srinivas Murthy |
author_sort | Raju, Kalyani |
collection | PubMed |
description | Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Approximately 50% of patients diagnosed with hemochromatosis will have either type 1 or type 2 diabetes mellitus (DM) because of selective beta-cell damage due to iron overload and leads to impaired insulin synthesis, release, and insulin resistance. Early diagnosis and treatment of hemochromatosis prevents the development of diabetes. We present a case in a 48-year-old male with a history of DM for 6 months and skin pigmentation over face for 1 year. |
format | Online Article Text |
id | pubmed-5846224 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-58462242018-03-16 Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature Raju, Kalyani Venkataramappa, Srinivas Murthy Int J Appl Basic Med Res Case Report Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Approximately 50% of patients diagnosed with hemochromatosis will have either type 1 or type 2 diabetes mellitus (DM) because of selective beta-cell damage due to iron overload and leads to impaired insulin synthesis, release, and insulin resistance. Early diagnosis and treatment of hemochromatosis prevents the development of diabetes. We present a case in a 48-year-old male with a history of DM for 6 months and skin pigmentation over face for 1 year. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5846224/ /pubmed/29552540 http://dx.doi.org/10.4103/ijabmr.IJABMR_402_16 Text en Copyright: © 2018 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Case Report Raju, Kalyani Venkataramappa, Srinivas Murthy Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature |
title | Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature |
title_full | Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature |
title_fullStr | Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature |
title_full_unstemmed | Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature |
title_short | Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature |
title_sort | primary hemochromatosis presenting as type 2 diabetes mellitus: a case report with review of literature |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846224/ https://www.ncbi.nlm.nih.gov/pubmed/29552540 http://dx.doi.org/10.4103/ijabmr.IJABMR_402_16 |
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