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Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature

Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Appro...

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Autores principales: Raju, Kalyani, Venkataramappa, Srinivas Murthy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846224/
https://www.ncbi.nlm.nih.gov/pubmed/29552540
http://dx.doi.org/10.4103/ijabmr.IJABMR_402_16
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author Raju, Kalyani
Venkataramappa, Srinivas Murthy
author_facet Raju, Kalyani
Venkataramappa, Srinivas Murthy
author_sort Raju, Kalyani
collection PubMed
description Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Approximately 50% of patients diagnosed with hemochromatosis will have either type 1 or type 2 diabetes mellitus (DM) because of selective beta-cell damage due to iron overload and leads to impaired insulin synthesis, release, and insulin resistance. Early diagnosis and treatment of hemochromatosis prevents the development of diabetes. We present a case in a 48-year-old male with a history of DM for 6 months and skin pigmentation over face for 1 year.
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spelling pubmed-58462242018-03-16 Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature Raju, Kalyani Venkataramappa, Srinivas Murthy Int J Appl Basic Med Res Case Report Hemochromatosis is an autosomal recessive genetic disorder resulting in increased intestinal absorption of iron and eventually to iron overload. The onset of symptoms is usually seen around 40 years of age. Iron overload causes tissue damage in liver, pancreas, skin, joints, heart, and gonads. Approximately 50% of patients diagnosed with hemochromatosis will have either type 1 or type 2 diabetes mellitus (DM) because of selective beta-cell damage due to iron overload and leads to impaired insulin synthesis, release, and insulin resistance. Early diagnosis and treatment of hemochromatosis prevents the development of diabetes. We present a case in a 48-year-old male with a history of DM for 6 months and skin pigmentation over face for 1 year. Medknow Publications & Media Pvt Ltd 2018 /pmc/articles/PMC5846224/ /pubmed/29552540 http://dx.doi.org/10.4103/ijabmr.IJABMR_402_16 Text en Copyright: © 2018 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Case Report
Raju, Kalyani
Venkataramappa, Srinivas Murthy
Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
title Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
title_full Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
title_fullStr Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
title_full_unstemmed Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
title_short Primary Hemochromatosis Presenting as Type 2 Diabetes Mellitus: A Case Report with Review of Literature
title_sort primary hemochromatosis presenting as type 2 diabetes mellitus: a case report with review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846224/
https://www.ncbi.nlm.nih.gov/pubmed/29552540
http://dx.doi.org/10.4103/ijabmr.IJABMR_402_16
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