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Extrinsic functional connectivity of the default mode network in crack-cocaine users
OBJECTIVE: This study aimed to explore the functional connectivity of the default mode network (DMN) in crack-cocaine users, in comparison with that observed in age-matched non-drug-using controls. MATERIALS AND METHODS: Inpatient crack-cocaine users who had been abstinent for at least four weeks an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Radiologia e Diagnóstico por
Imagem
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846319/ https://www.ncbi.nlm.nih.gov/pubmed/29559760 http://dx.doi.org/10.1590/0100-3984.2016.0115 |
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author | Martins, Diego Lima Nava Valiatti, Talles Destefani de Souza D'Ávila, Júlia Ferreira, Lucas Freire Batista, Edson Kruger Bazán, Paulo Rodrigo de Souza, Rodrigo Stênio Moll Nakamura-Palacios, Ester Miyuki |
author_facet | Martins, Diego Lima Nava Valiatti, Talles Destefani de Souza D'Ávila, Júlia Ferreira, Lucas Freire Batista, Edson Kruger Bazán, Paulo Rodrigo de Souza, Rodrigo Stênio Moll Nakamura-Palacios, Ester Miyuki |
author_sort | Martins, Diego Lima Nava |
collection | PubMed |
description | OBJECTIVE: This study aimed to explore the functional connectivity of the default mode network (DMN) in crack-cocaine users, in comparison with that observed in age-matched non-drug-using controls. MATERIALS AND METHODS: Inpatient crack-cocaine users who had been abstinent for at least four weeks and age-matched non-drug-using controls underwent resting state functional magnetic resonance imaging. Images were acquired while the subjects rested with their eyes closed. After data preprocessing, DMNs were defined by spatial independent component analysis and seed-based correlation analysis, by chosen regions of interest centered in the ventral anterior cingulate cortex and in the posterior cingulate cortex. RESULTS: The functional connectivity of the DMN determined by independent component analysis did not differ between the crack-cocaine users and the controls. However, the seed-based correlation analysis seeking a single metric of functional connectivity between specific brain regions showed that the negative connectivity between the ventral anterior cingulate cortex and the left superior parietal lobule was significantly greater in the crack-cocaine users than in the controls. CONCLUSION: The results suggest that selective extrinsic network connectivity of the DMN related to motor and executive function is impaired during crack-cocaine addiction. |
format | Online Article Text |
id | pubmed-5846319 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Colégio Brasileiro de Radiologia e Diagnóstico por
Imagem |
record_format | MEDLINE/PubMed |
spelling | pubmed-58463192018-03-20 Extrinsic functional connectivity of the default mode network in crack-cocaine users Martins, Diego Lima Nava Valiatti, Talles Destefani de Souza D'Ávila, Júlia Ferreira, Lucas Freire Batista, Edson Kruger Bazán, Paulo Rodrigo de Souza, Rodrigo Stênio Moll Nakamura-Palacios, Ester Miyuki Radiol Bras Original Articles OBJECTIVE: This study aimed to explore the functional connectivity of the default mode network (DMN) in crack-cocaine users, in comparison with that observed in age-matched non-drug-using controls. MATERIALS AND METHODS: Inpatient crack-cocaine users who had been abstinent for at least four weeks and age-matched non-drug-using controls underwent resting state functional magnetic resonance imaging. Images were acquired while the subjects rested with their eyes closed. After data preprocessing, DMNs were defined by spatial independent component analysis and seed-based correlation analysis, by chosen regions of interest centered in the ventral anterior cingulate cortex and in the posterior cingulate cortex. RESULTS: The functional connectivity of the DMN determined by independent component analysis did not differ between the crack-cocaine users and the controls. However, the seed-based correlation analysis seeking a single metric of functional connectivity between specific brain regions showed that the negative connectivity between the ventral anterior cingulate cortex and the left superior parietal lobule was significantly greater in the crack-cocaine users than in the controls. CONCLUSION: The results suggest that selective extrinsic network connectivity of the DMN related to motor and executive function is impaired during crack-cocaine addiction. Colégio Brasileiro de Radiologia e Diagnóstico por Imagem 2018 /pmc/articles/PMC5846319/ /pubmed/29559760 http://dx.doi.org/10.1590/0100-3984.2016.0115 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Martins, Diego Lima Nava Valiatti, Talles Destefani de Souza D'Ávila, Júlia Ferreira, Lucas Freire Batista, Edson Kruger Bazán, Paulo Rodrigo de Souza, Rodrigo Stênio Moll Nakamura-Palacios, Ester Miyuki Extrinsic functional connectivity of the default mode network in crack-cocaine users |
title | Extrinsic functional connectivity of the default mode network in
crack-cocaine users |
title_full | Extrinsic functional connectivity of the default mode network in
crack-cocaine users |
title_fullStr | Extrinsic functional connectivity of the default mode network in
crack-cocaine users |
title_full_unstemmed | Extrinsic functional connectivity of the default mode network in
crack-cocaine users |
title_short | Extrinsic functional connectivity of the default mode network in
crack-cocaine users |
title_sort | extrinsic functional connectivity of the default mode network in
crack-cocaine users |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846319/ https://www.ncbi.nlm.nih.gov/pubmed/29559760 http://dx.doi.org/10.1590/0100-3984.2016.0115 |
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