Cargando…
Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846367/ https://www.ncbi.nlm.nih.gov/pubmed/29682542 http://dx.doi.org/10.1155/2018/4178607 |
_version_ | 1783305575007780864 |
---|---|
author | Vemuri, Ravichandra Gundamaraju, Rohit Shastri, Madhur D. Shukla, Shakti Dhar Kalpurath, Krishnakumar Ball, Madeleine Tristram, Stephen Shankar, Esaki M. Ahuja, Kiran Eri, Rajaraman |
author_facet | Vemuri, Ravichandra Gundamaraju, Rohit Shastri, Madhur D. Shukla, Shakti Dhar Kalpurath, Krishnakumar Ball, Madeleine Tristram, Stephen Shankar, Esaki M. Ahuja, Kiran Eri, Rajaraman |
author_sort | Vemuri, Ravichandra |
collection | PubMed |
description | Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem. This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics. In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored. The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing. The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state. |
format | Online Article Text |
id | pubmed-5846367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58463672018-04-22 Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective Vemuri, Ravichandra Gundamaraju, Rohit Shastri, Madhur D. Shukla, Shakti Dhar Kalpurath, Krishnakumar Ball, Madeleine Tristram, Stephen Shankar, Esaki M. Ahuja, Kiran Eri, Rajaraman Biomed Res Int Review Article Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem. This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics. In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored. The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing. The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state. Hindawi 2018-02-26 /pmc/articles/PMC5846367/ /pubmed/29682542 http://dx.doi.org/10.1155/2018/4178607 Text en Copyright © 2018 Ravichandra Vemuri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Vemuri, Ravichandra Gundamaraju, Rohit Shastri, Madhur D. Shukla, Shakti Dhar Kalpurath, Krishnakumar Ball, Madeleine Tristram, Stephen Shankar, Esaki M. Ahuja, Kiran Eri, Rajaraman Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective |
title | Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective |
title_full | Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective |
title_fullStr | Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective |
title_full_unstemmed | Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective |
title_short | Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective |
title_sort | gut microbial changes, interactions, and their implications on human lifecycle: an ageing perspective |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846367/ https://www.ncbi.nlm.nih.gov/pubmed/29682542 http://dx.doi.org/10.1155/2018/4178607 |
work_keys_str_mv | AT vemuriravichandra gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT gundamarajurohit gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT shastrimadhurd gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT shuklashaktidhar gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT kalpurathkrishnakumar gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT ballmadeleine gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT tristramstephen gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT shankaresakim gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT ahujakiran gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective AT erirajaraman gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective |