Cargando…

Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective

Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant...

Descripción completa

Detalles Bibliográficos
Autores principales: Vemuri, Ravichandra, Gundamaraju, Rohit, Shastri, Madhur D., Shukla, Shakti Dhar, Kalpurath, Krishnakumar, Ball, Madeleine, Tristram, Stephen, Shankar, Esaki M., Ahuja, Kiran, Eri, Rajaraman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846367/
https://www.ncbi.nlm.nih.gov/pubmed/29682542
http://dx.doi.org/10.1155/2018/4178607
_version_ 1783305575007780864
author Vemuri, Ravichandra
Gundamaraju, Rohit
Shastri, Madhur D.
Shukla, Shakti Dhar
Kalpurath, Krishnakumar
Ball, Madeleine
Tristram, Stephen
Shankar, Esaki M.
Ahuja, Kiran
Eri, Rajaraman
author_facet Vemuri, Ravichandra
Gundamaraju, Rohit
Shastri, Madhur D.
Shukla, Shakti Dhar
Kalpurath, Krishnakumar
Ball, Madeleine
Tristram, Stephen
Shankar, Esaki M.
Ahuja, Kiran
Eri, Rajaraman
author_sort Vemuri, Ravichandra
collection PubMed
description Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem. This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics. In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored. The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing. The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state.
format Online
Article
Text
id pubmed-5846367
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-58463672018-04-22 Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective Vemuri, Ravichandra Gundamaraju, Rohit Shastri, Madhur D. Shukla, Shakti Dhar Kalpurath, Krishnakumar Ball, Madeleine Tristram, Stephen Shankar, Esaki M. Ahuja, Kiran Eri, Rajaraman Biomed Res Int Review Article Gut microbiota is established during birth and evolves with age, mostly maintaining the commensal relationship with the host. A growing body of clinical evidence suggests an intricate relationship between the gut microbiota and the immune system. With ageing, the gut microbiota develops significant imbalances in the major phyla such as the anaerobic Firmicutes and Bacteroidetes as well as a diverse range of facultative organisms, resulting in impaired immune responses. Antimicrobial therapy is commonly used for the treatment of infections; however, this may also result in the loss of normal gut flora. Advanced age, antibiotic use, underlying diseases, infections, hormonal differences, circadian rhythm, and malnutrition, either alone or in combination, contribute to the problem. This nonbeneficial gastrointestinal modulation may be reversed by judicious and controlled use of antibiotics and the appropriate use of prebiotics and probiotics. In certain persistent, recurrent settings, the option of faecal microbiota transplantation can be explored. The aim of the current review is to focus on the establishment and alteration of gut microbiota, with ageing. The review also discusses the potential role of gut microbiota in regulating the immune system, together with its function in healthy and diseased state. Hindawi 2018-02-26 /pmc/articles/PMC5846367/ /pubmed/29682542 http://dx.doi.org/10.1155/2018/4178607 Text en Copyright © 2018 Ravichandra Vemuri et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vemuri, Ravichandra
Gundamaraju, Rohit
Shastri, Madhur D.
Shukla, Shakti Dhar
Kalpurath, Krishnakumar
Ball, Madeleine
Tristram, Stephen
Shankar, Esaki M.
Ahuja, Kiran
Eri, Rajaraman
Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
title Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
title_full Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
title_fullStr Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
title_full_unstemmed Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
title_short Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective
title_sort gut microbial changes, interactions, and their implications on human lifecycle: an ageing perspective
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846367/
https://www.ncbi.nlm.nih.gov/pubmed/29682542
http://dx.doi.org/10.1155/2018/4178607
work_keys_str_mv AT vemuriravichandra gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT gundamarajurohit gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT shastrimadhurd gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT shuklashaktidhar gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT kalpurathkrishnakumar gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT ballmadeleine gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT tristramstephen gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT shankaresakim gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT ahujakiran gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective
AT erirajaraman gutmicrobialchangesinteractionsandtheirimplicationsonhumanlifecycleanageingperspective