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Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits

BACKGROUND: This study aims to analyze the effect of Semelil, an herbal selenium-based medicine, on osteogenesis in rabbit calvarium defects. METHODS: Four identical bony defects (8 mm) were created in the calvarium of 16 New Zealand male rabbits and filled randomly with xenogenic bone substitute ma...

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Autores principales: Rasouli-Ghahroudi, Amir Alireza, Rokn, Amirreza, Abdollahi, Mohammad, Mashhadi-Abbas, Fatemeh, Yaghobee, Siamak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846393/
https://www.ncbi.nlm.nih.gov/pubmed/29682529
http://dx.doi.org/10.1155/2018/2860367
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author Rasouli-Ghahroudi, Amir Alireza
Rokn, Amirreza
Abdollahi, Mohammad
Mashhadi-Abbas, Fatemeh
Yaghobee, Siamak
author_facet Rasouli-Ghahroudi, Amir Alireza
Rokn, Amirreza
Abdollahi, Mohammad
Mashhadi-Abbas, Fatemeh
Yaghobee, Siamak
author_sort Rasouli-Ghahroudi, Amir Alireza
collection PubMed
description BACKGROUND: This study aims to analyze the effect of Semelil, an herbal selenium-based medicine, on osteogenesis in rabbit calvarium defects. METHODS: Four identical bony defects (8 mm) were created in the calvarium of 16 New Zealand male rabbits and filled randomly with xenogenic bone substitute material (Bio-Oss®) and semelil herbal drug (ANGIPARS™). One site was filled with Bio-Oss (B); the second site was treated with ANGIPARS (A); the third site was treated with ANGIPARS + Bio-Oss (AB); and the fourth site was left as untreated control (C) and defects were left unfilled. Rabbits were randomly divided into two groups (n = 8) and sacrificed at four and eight weeks. Percentage of new bone formation, type of the newly formed bone, percentage of the remaining xenograft biomaterial, and foreign body reaction (FBR) were evaluated via histological and histomorphometric analyses. RESULTS: The percentage of new bone formation was significantly different among four groups. The highest effect was observed in AB, followed by A, B, and C groups, respectively. The difference in the mean percentage of new bone formation between four and eight weeks was significant for all four groups (P < 0.001). Regarding bone formation, the interaction effect of A and B was significant at four (P < 0.001) and eight weeks (P = 0.002). ANGIPARS alone and in presence of Bio-Oss enhanced new bone formation at both four and eight weeks (P < 0.001). The mean amount of new bone formation was significantly different at four and eight weeks in groups C (P = 0.008), A (P < 0.001), B (P < 0.001), and AB (P = 0.003). FBR was not observed in any group. CONCLUSION: Semelil may be useful as an adjunct to conventional osteoconductive materials in order to enhance osteogenesis.
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spelling pubmed-58463932018-04-22 Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits Rasouli-Ghahroudi, Amir Alireza Rokn, Amirreza Abdollahi, Mohammad Mashhadi-Abbas, Fatemeh Yaghobee, Siamak Biomed Res Int Research Article BACKGROUND: This study aims to analyze the effect of Semelil, an herbal selenium-based medicine, on osteogenesis in rabbit calvarium defects. METHODS: Four identical bony defects (8 mm) were created in the calvarium of 16 New Zealand male rabbits and filled randomly with xenogenic bone substitute material (Bio-Oss®) and semelil herbal drug (ANGIPARS™). One site was filled with Bio-Oss (B); the second site was treated with ANGIPARS (A); the third site was treated with ANGIPARS + Bio-Oss (AB); and the fourth site was left as untreated control (C) and defects were left unfilled. Rabbits were randomly divided into two groups (n = 8) and sacrificed at four and eight weeks. Percentage of new bone formation, type of the newly formed bone, percentage of the remaining xenograft biomaterial, and foreign body reaction (FBR) were evaluated via histological and histomorphometric analyses. RESULTS: The percentage of new bone formation was significantly different among four groups. The highest effect was observed in AB, followed by A, B, and C groups, respectively. The difference in the mean percentage of new bone formation between four and eight weeks was significant for all four groups (P < 0.001). Regarding bone formation, the interaction effect of A and B was significant at four (P < 0.001) and eight weeks (P = 0.002). ANGIPARS alone and in presence of Bio-Oss enhanced new bone formation at both four and eight weeks (P < 0.001). The mean amount of new bone formation was significantly different at four and eight weeks in groups C (P = 0.008), A (P < 0.001), B (P < 0.001), and AB (P = 0.003). FBR was not observed in any group. CONCLUSION: Semelil may be useful as an adjunct to conventional osteoconductive materials in order to enhance osteogenesis. Hindawi 2018-02-26 /pmc/articles/PMC5846393/ /pubmed/29682529 http://dx.doi.org/10.1155/2018/2860367 Text en Copyright © 2018 Amir Alireza Rasouli-Ghahroudi et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rasouli-Ghahroudi, Amir Alireza
Rokn, Amirreza
Abdollahi, Mohammad
Mashhadi-Abbas, Fatemeh
Yaghobee, Siamak
Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
title Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
title_full Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
title_fullStr Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
title_full_unstemmed Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
title_short Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits
title_sort effect of semelil, an herbal selenium-based medicine, on new bone formation in calvarium of rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846393/
https://www.ncbi.nlm.nih.gov/pubmed/29682529
http://dx.doi.org/10.1155/2018/2860367
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