Targeting potassium channels to treat cerebellar ataxia

OBJECTIVE: Purkinje neuron dysfunction is associated with cerebellar ataxia. In a mouse model of spinocerebellar ataxia type 1 (SCA1), reduced potassium channel function contributes to altered membrane excitability resulting in impaired Purkinje neuron spiking. We sought to determine the relationshi...

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Detalles Bibliográficos
Autores principales: Bushart, David D., Chopra, Ravi, Singh, Vikrant, Murphy, Geoffrey G., Wulff, Heike, Shakkottai, Vikram G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846455/
https://www.ncbi.nlm.nih.gov/pubmed/29560375
http://dx.doi.org/10.1002/acn3.527

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