Markers of Oral Lichen Planus Malignant Transformation

Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy...

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Autores principales: Tampa, Mircea, Caruntu, Constantin, Mitran, Madalina, Mitran, Cristina, Sarbu, Isabela, Rusu, Laura-Cristina, Matei, Clara, Constantin, Carolina, Neagu, Monica, Georgescu, Simona-Roxana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846459/
https://www.ncbi.nlm.nih.gov/pubmed/29682099
http://dx.doi.org/10.1155/2018/1959506
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author Tampa, Mircea
Caruntu, Constantin
Mitran, Madalina
Mitran, Cristina
Sarbu, Isabela
Rusu, Laura-Cristina
Matei, Clara
Constantin, Carolina
Neagu, Monica
Georgescu, Simona-Roxana
author_facet Tampa, Mircea
Caruntu, Constantin
Mitran, Madalina
Mitran, Cristina
Sarbu, Isabela
Rusu, Laura-Cristina
Matei, Clara
Constantin, Carolina
Neagu, Monica
Georgescu, Simona-Roxana
author_sort Tampa, Mircea
collection PubMed
description Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation.
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spelling pubmed-58464592018-04-22 Markers of Oral Lichen Planus Malignant Transformation Tampa, Mircea Caruntu, Constantin Mitran, Madalina Mitran, Cristina Sarbu, Isabela Rusu, Laura-Cristina Matei, Clara Constantin, Carolina Neagu, Monica Georgescu, Simona-Roxana Dis Markers Review Article Oral lichen planus (OLP) is a chronic inflammatory disease of unknown etiology with significant impact on patients' quality of life. Malignant transformation into oral squamous cell carcinoma (OSCC) is considered as one of the most serious complications of the disease; nevertheless, controversy still persists. Various factors seem to be involved in the progression of malignant transformation; however, the mechanism of this process is not fully understood yet. Molecular alterations detected in OLP samples might represent useful biomarkers for predicting and monitoring the malignant progression. In this review, we discuss various studies which highlight different molecules as ominous predictors of OLP malignant transformation. Hindawi 2018-02-26 /pmc/articles/PMC5846459/ /pubmed/29682099 http://dx.doi.org/10.1155/2018/1959506 Text en Copyright © 2018 Mircea Tampa et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tampa, Mircea
Caruntu, Constantin
Mitran, Madalina
Mitran, Cristina
Sarbu, Isabela
Rusu, Laura-Cristina
Matei, Clara
Constantin, Carolina
Neagu, Monica
Georgescu, Simona-Roxana
Markers of Oral Lichen Planus Malignant Transformation
title Markers of Oral Lichen Planus Malignant Transformation
title_full Markers of Oral Lichen Planus Malignant Transformation
title_fullStr Markers of Oral Lichen Planus Malignant Transformation
title_full_unstemmed Markers of Oral Lichen Planus Malignant Transformation
title_short Markers of Oral Lichen Planus Malignant Transformation
title_sort markers of oral lichen planus malignant transformation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846459/
https://www.ncbi.nlm.nih.gov/pubmed/29682099
http://dx.doi.org/10.1155/2018/1959506
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