Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients

BACKGROUND & AIMS: The causes of gastrointestinal complaints in irritable bowel syndrome (IBS) remain poorly understood. Altered nerve function has emerged as an important pathogenic factor as IBS mucosal biopsy supernatants consistently activate enteric and sensory neurons. We investigated the...

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Detalles Bibliográficos
Autores principales: Buhner, Sabine, Hahne, Hannes, Hartwig, Kerstin, Li, Qin, Vignali, Sheila, Ostertag, Daniela, Meng, Chen, Hörmannsperger, Gabriele, Braak, Breg, Pehl, Christian, Frieling, Thomas, Barbara, Giovanni, De Giorgio, Roberto, Demir, Ihsan Ekin, Ceyhan, Güralp Onur, Zeller, Florian, Boeckxstaens, Guy, Haller, Dirk, Kuster, Bernhard, Schemann, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846775/
https://www.ncbi.nlm.nih.gov/pubmed/29529042
http://dx.doi.org/10.1371/journal.pone.0193943

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