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Epidemiological and histological findings implicate matrix Gla protein in diastolic left ventricular dysfunction

OBJECTIVES: A novel paradigm of diastolic left ventricular (LV) dysfunction proposes involvement of the cardiac microvasculature. Vitamin K dependent matrix Gla protein (MGP) plays a role in preserving microcirculatory integrity. We hypothesized that LV filling pressure–a measure of diastolic LV dys...

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Detalles Bibliográficos
Autores principales:	Wei, Fang-Fei, Trenson, Sander, Monney, Pierre, Yang, Wen-Yi, Pruijm, Menno, Zhang, Zhen-Yu, Bouatou, Yassine, Huang, Qi-Fang, Ponte, Belen, Martin, Pierre-Yves, Thijs, Lutgarde, Kuznetsova, Tatiana, Allegaert, Karel, Janssens, Stefan, Vermeer, Cees, Verhamme, Peter, Burnier, Michel, Bochud, Murielle, Ehret, Georg, Staessen, Jan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846787/ https://www.ncbi.nlm.nih.gov/pubmed/29529056 http://dx.doi.org/10.1371/journal.pone.0193967

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