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The long-term survival of stage IV gastric cancer patients with conversion therapy
PURPOSE: A retrospective study was performed to clarify the role of conversion therapy (surgery with a prospect of R0 resection performed in initially unresectable metastatic cancer that responded to the chemotherapy) in stage IV gastric cancer (GC). PATIENTS AND METHODS: We treated 259 stage IV GC...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Japan
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846815/ https://www.ncbi.nlm.nih.gov/pubmed/28616743 http://dx.doi.org/10.1007/s10120-017-0738-1 |
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author | Yamaguchi, Kazuya Yoshida, Kazuhiro Tanahashi, Toshiyuki Takahashi, Takao Matsuhashi, Nobuhisa Tanaka, Yoshihiro Tanabe, Kazuaki Ohdan, Hideki |
author_facet | Yamaguchi, Kazuya Yoshida, Kazuhiro Tanahashi, Toshiyuki Takahashi, Takao Matsuhashi, Nobuhisa Tanaka, Yoshihiro Tanabe, Kazuaki Ohdan, Hideki |
author_sort | Yamaguchi, Kazuya |
collection | PubMed |
description | PURPOSE: A retrospective study was performed to clarify the role of conversion therapy (surgery with a prospect of R0 resection performed in initially unresectable metastatic cancer that responded to the chemotherapy) in stage IV gastric cancer (GC). PATIENTS AND METHODS: We treated 259 stage IV GC patients with systemic chemotherapy at Gifu and Hiroshima University Hospitals between 2001–2013. Of these, 84 patients who were subsequently treated by surgery were classified into four categories according to our previously published classification of stage IV GC, and short- and long-term outcomes were analyzed. RESULTS: Surgery was performed in 84 patients, of which 7 were performed following the neoadjuvant chemotherapy, whereas the other 77 that excluded neoadjuvant chemotherapy cases were considered the conversion therapy. The postoperative mortality and morbidity were comparable with those reported clinical trials. The MSTs of the patients with/without surgery for each category were 28.3/5.8 months for category 1, 30.5/11.0 months for category 2, 31.0/18.5 months for category 3 and 24.7/10.0 months for category 4. The MST of the R0 resected patients (41.3 months) was far better than that of the R1–2 resected patients (21.2 months). The MSTs of the patients with R0/R1–2 resection were 56.2/16.3 months for category 2, 33.3/29.6 months for category 3 and 40.7/17.8 months for category 4. CONCLUSION: There were long-term survivors who underwent conversion therapy for stage IV GC. Adequate selection of stage IV GC patients for conversion therapy may be an important role for the surgical oncologist in the new era. |
format | Online Article Text |
id | pubmed-5846815 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-58468152018-03-20 The long-term survival of stage IV gastric cancer patients with conversion therapy Yamaguchi, Kazuya Yoshida, Kazuhiro Tanahashi, Toshiyuki Takahashi, Takao Matsuhashi, Nobuhisa Tanaka, Yoshihiro Tanabe, Kazuaki Ohdan, Hideki Gastric Cancer Original Article PURPOSE: A retrospective study was performed to clarify the role of conversion therapy (surgery with a prospect of R0 resection performed in initially unresectable metastatic cancer that responded to the chemotherapy) in stage IV gastric cancer (GC). PATIENTS AND METHODS: We treated 259 stage IV GC patients with systemic chemotherapy at Gifu and Hiroshima University Hospitals between 2001–2013. Of these, 84 patients who were subsequently treated by surgery were classified into four categories according to our previously published classification of stage IV GC, and short- and long-term outcomes were analyzed. RESULTS: Surgery was performed in 84 patients, of which 7 were performed following the neoadjuvant chemotherapy, whereas the other 77 that excluded neoadjuvant chemotherapy cases were considered the conversion therapy. The postoperative mortality and morbidity were comparable with those reported clinical trials. The MSTs of the patients with/without surgery for each category were 28.3/5.8 months for category 1, 30.5/11.0 months for category 2, 31.0/18.5 months for category 3 and 24.7/10.0 months for category 4. The MST of the R0 resected patients (41.3 months) was far better than that of the R1–2 resected patients (21.2 months). The MSTs of the patients with R0/R1–2 resection were 56.2/16.3 months for category 2, 33.3/29.6 months for category 3 and 40.7/17.8 months for category 4. CONCLUSION: There were long-term survivors who underwent conversion therapy for stage IV GC. Adequate selection of stage IV GC patients for conversion therapy may be an important role for the surgical oncologist in the new era. Springer Japan 2017-06-14 2018 /pmc/articles/PMC5846815/ /pubmed/28616743 http://dx.doi.org/10.1007/s10120-017-0738-1 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Article Yamaguchi, Kazuya Yoshida, Kazuhiro Tanahashi, Toshiyuki Takahashi, Takao Matsuhashi, Nobuhisa Tanaka, Yoshihiro Tanabe, Kazuaki Ohdan, Hideki The long-term survival of stage IV gastric cancer patients with conversion therapy |
title | The long-term survival of stage IV gastric cancer patients with conversion therapy |
title_full | The long-term survival of stage IV gastric cancer patients with conversion therapy |
title_fullStr | The long-term survival of stage IV gastric cancer patients with conversion therapy |
title_full_unstemmed | The long-term survival of stage IV gastric cancer patients with conversion therapy |
title_short | The long-term survival of stage IV gastric cancer patients with conversion therapy |
title_sort | long-term survival of stage iv gastric cancer patients with conversion therapy |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846815/ https://www.ncbi.nlm.nih.gov/pubmed/28616743 http://dx.doi.org/10.1007/s10120-017-0738-1 |
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