Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos

Failure of neural tube closure in the early embryo causes neural tube defects including spina bifida. Spina bifida lesions predominate in the distal spine, particularly after exposure to the anticonvulsant valproic acid (VPA). How VPA specifically disturbs late stages of neural tube closure is uncle...

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Detalles Bibliográficos
Autores principales: Hughes, Amy, Greene, Nicholas D.E., Copp, Andrew J., Galea, Gabriel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846844/
https://www.ncbi.nlm.nih.gov/pubmed/29225143
http://dx.doi.org/10.1016/j.mod.2017.12.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846844/
https://www.ncbi.nlm.nih.gov/pubmed/29225143
http://dx.doi.org/10.1016/j.mod.2017.12.001

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