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Valproic acid disrupts the biomechanics of late spinal neural tube closure in mouse embryos
Failure of neural tube closure in the early embryo causes neural tube defects including spina bifida. Spina bifida lesions predominate in the distal spine, particularly after exposure to the anticonvulsant valproic acid (VPA). How VPA specifically disturbs late stages of neural tube closure is uncle...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846844/ https://www.ncbi.nlm.nih.gov/pubmed/29225143 http://dx.doi.org/10.1016/j.mod.2017.12.001 |