NOLAN: a randomized, phase 2 study to estimate the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on bone pain in patients with early-stage breast cancer receiving chemotherapy and pegfilgrastim

PURPOSE: Mild-to-moderate bone pain is a commonly reported adverse event (AE) associated with pegfilgrastim. We evaluated the effect of prophylactic naproxen or loratadine vs no prophylactic treatment on pegfilgrastim-associated bone pain. METHODS: In this open-label study (NCT01712009), women ≥ 18 ...

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Detalles Bibliográficos
Autores principales: Kirshner, Jeffrey J., McDonald, Maxwell C., Kruter, Flavio, Guinigundo, Andrew S., Vanni, Linda, Maxwell, Cathy L., Reiner, Maureen, Upchurch, Terry E., Garcia, Jacob, Morrow, Phuong Khanh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847062/
https://www.ncbi.nlm.nih.gov/pubmed/29147854
http://dx.doi.org/10.1007/s00520-017-3959-2

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