Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847079/ https://www.ncbi.nlm.nih.gov/pubmed/29197982 http://dx.doi.org/10.1007/s00213-017-4801-8 |
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author | Mohammed Jawad, Rafat A. Hutchinson, Claire V. Prados, Jose |
author_facet | Mohammed Jawad, Rafat A. Hutchinson, Claire V. Prados, Jose |
author_sort | Mohammed Jawad, Rafat A. |
collection | PubMed |
description | In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system. |
format | Online Article Text |
id | pubmed-5847079 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-58470792018-03-20 Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian Mohammed Jawad, Rafat A. Hutchinson, Claire V. Prados, Jose Psychopharmacology (Berl) Original Investigation In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system. Springer Berlin Heidelberg 2017-12-02 2018 /pmc/articles/PMC5847079/ /pubmed/29197982 http://dx.doi.org/10.1007/s00213-017-4801-8 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Original Investigation Mohammed Jawad, Rafat A. Hutchinson, Claire V. Prados, Jose Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
title | Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
title_full | Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
title_fullStr | Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
title_full_unstemmed | Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
title_short | Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
title_sort | dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847079/ https://www.ncbi.nlm.nih.gov/pubmed/29197982 http://dx.doi.org/10.1007/s00213-017-4801-8 |
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