Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian

In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive...

Descripción completa

Detalles Bibliográficos
Autores principales: Mohammed Jawad, Rafat A., Hutchinson, Claire V., Prados, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847079/
https://www.ncbi.nlm.nih.gov/pubmed/29197982
http://dx.doi.org/10.1007/s00213-017-4801-8
_version_ 1783305684183416832
author Mohammed Jawad, Rafat A.
Hutchinson, Claire V.
Prados, Jose
author_facet Mohammed Jawad, Rafat A.
Hutchinson, Claire V.
Prados, Jose
author_sort Mohammed Jawad, Rafat A.
collection PubMed
description In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system.
format Online
Article
Text
id pubmed-5847079
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-58470792018-03-20 Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian Mohammed Jawad, Rafat A. Hutchinson, Claire V. Prados, Jose Psychopharmacology (Berl) Original Investigation In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system. Springer Berlin Heidelberg 2017-12-02 2018 /pmc/articles/PMC5847079/ /pubmed/29197982 http://dx.doi.org/10.1007/s00213-017-4801-8 Text en © The Author(s) 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Investigation
Mohammed Jawad, Rafat A.
Hutchinson, Claire V.
Prados, Jose
Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
title Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
title_full Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
title_fullStr Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
title_full_unstemmed Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
title_short Dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
title_sort dissociation of place preference and tolerance responses to sucrose using a dopamine antagonist in the planarian
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847079/
https://www.ncbi.nlm.nih.gov/pubmed/29197982
http://dx.doi.org/10.1007/s00213-017-4801-8
work_keys_str_mv AT mohammedjawadrafata dissociationofplacepreferenceandtoleranceresponsestosucroseusingadopamineantagonistintheplanarian
AT hutchinsonclairev dissociationofplacepreferenceandtoleranceresponsestosucroseusingadopamineantagonistintheplanarian
AT pradosjose dissociationofplacepreferenceandtoleranceresponsestosucroseusingadopamineantagonistintheplanarian