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Ligand-induced perturbation of the HIF-2α:ARNT dimer dynamics

Hypoxia inducible factors (HIFs) are transcription factors belonging to the basic helix−loop−helix PER-ARNT-SIM (bHLH-PAS) protein family with a role in sensing oxygen levels in the cell. Under hypoxia, the HIF-α degradation pathway is blocked and dimerization with the aryl hydrocarbon receptor nucl...

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Detalles Bibliográficos
Autores principales:	Motta, Stefano, Minici, Claudia, Corrada, Dario, Bonati, Laura, Pandini, Alessandro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847239/ https://www.ncbi.nlm.nih.gov/pubmed/29489822 http://dx.doi.org/10.1371/journal.pcbi.1006021

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