UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes

This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass sp...

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Detalles Bibliográficos
Autores principales: Saad, Moayad, Bijttebier, Sebastiaan, Matheeussen, An, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Van Ginneken, Chris, Maes, Louis, Cos, Paul, Van Cruchten, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Pharmacology, Toxicology and Pharmaceutical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847491/
https://www.ncbi.nlm.nih.gov/pubmed/29541660
http://dx.doi.org/10.1016/j.dib.2017.11.079
Descripción
Sumario:This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM). Data are expressed as the abundance from the extracted ion chromatogram of the metabolites.

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