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UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes

This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass sp...

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Autores principales: Saad, Moayad, Bijttebier, Sebastiaan, Matheeussen, An, Verbueken, Evy, Pype, Casper, Casteleyn, Christophe, Van Ginneken, Chris, Maes, Louis, Cos, Paul, Van Cruchten, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847491/
https://www.ncbi.nlm.nih.gov/pubmed/29541660
http://dx.doi.org/10.1016/j.dib.2017.11.079
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author Saad, Moayad
Bijttebier, Sebastiaan
Matheeussen, An
Verbueken, Evy
Pype, Casper
Casteleyn, Christophe
Van Ginneken, Chris
Maes, Louis
Cos, Paul
Van Cruchten, Steven
author_facet Saad, Moayad
Bijttebier, Sebastiaan
Matheeussen, An
Verbueken, Evy
Pype, Casper
Casteleyn, Christophe
Van Ginneken, Chris
Maes, Louis
Cos, Paul
Van Cruchten, Steven
author_sort Saad, Moayad
collection PubMed
description This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM). Data are expressed as the abundance from the extracted ion chromatogram of the metabolites.
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spelling pubmed-58474912018-03-14 UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes Saad, Moayad Bijttebier, Sebastiaan Matheeussen, An Verbueken, Evy Pype, Casper Casteleyn, Christophe Van Ginneken, Chris Maes, Louis Cos, Paul Van Cruchten, Steven Data Brief Pharmacology, Toxicology and Pharmaceutical Science This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM). Data are expressed as the abundance from the extracted ion chromatogram of the metabolites. Elsevier 2017-12-06 /pmc/articles/PMC5847491/ /pubmed/29541660 http://dx.doi.org/10.1016/j.dib.2017.11.079 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Pharmacology, Toxicology and Pharmaceutical Science
Saad, Moayad
Bijttebier, Sebastiaan
Matheeussen, An
Verbueken, Evy
Pype, Casper
Casteleyn, Christophe
Van Ginneken, Chris
Maes, Louis
Cos, Paul
Van Cruchten, Steven
UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
title UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
title_full UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
title_fullStr UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
title_full_unstemmed UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
title_short UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
title_sort uplc/ms ms data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
topic Pharmacology, Toxicology and Pharmaceutical Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847491/
https://www.ncbi.nlm.nih.gov/pubmed/29541660
http://dx.doi.org/10.1016/j.dib.2017.11.079
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