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UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes
This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass sp...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847491/ https://www.ncbi.nlm.nih.gov/pubmed/29541660 http://dx.doi.org/10.1016/j.dib.2017.11.079 |
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author | Saad, Moayad Bijttebier, Sebastiaan Matheeussen, An Verbueken, Evy Pype, Casper Casteleyn, Christophe Van Ginneken, Chris Maes, Louis Cos, Paul Van Cruchten, Steven |
author_facet | Saad, Moayad Bijttebier, Sebastiaan Matheeussen, An Verbueken, Evy Pype, Casper Casteleyn, Christophe Van Ginneken, Chris Maes, Louis Cos, Paul Van Cruchten, Steven |
author_sort | Saad, Moayad |
collection | PubMed |
description | This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM). Data are expressed as the abundance from the extracted ion chromatogram of the metabolites. |
format | Online Article Text |
id | pubmed-5847491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-58474912018-03-14 UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes Saad, Moayad Bijttebier, Sebastiaan Matheeussen, An Verbueken, Evy Pype, Casper Casteleyn, Christophe Van Ginneken, Chris Maes, Louis Cos, Paul Van Cruchten, Steven Data Brief Pharmacology, Toxicology and Pharmaceutical Science This article represents data regarding a study published in Toxicology in vitro entitled “ in vitro CYP-mediated drug metabolism in the zebrafish (embryo) using human reference compounds” (Saad et al., 2017) [1]. Data were acquired with ultra-performance liquid chromatography – accurate mass mass spectrometry (UPLC-amMS). A full spectrum scan was conducted for the testosterone (TST) metabolites from the microsomal stability assay in zebrafish and humans. The microsomal proteins were extracted from adult zebrafish male (MLM) and female (FLM) livers, whole body homogenates of 96 h post fertilization larvae (EM) and a pool of human liver microsomes from 50 donors (HLM). Data are expressed as the abundance from the extracted ion chromatogram of the metabolites. Elsevier 2017-12-06 /pmc/articles/PMC5847491/ /pubmed/29541660 http://dx.doi.org/10.1016/j.dib.2017.11.079 Text en © 2017 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Pharmacology, Toxicology and Pharmaceutical Science Saad, Moayad Bijttebier, Sebastiaan Matheeussen, An Verbueken, Evy Pype, Casper Casteleyn, Christophe Van Ginneken, Chris Maes, Louis Cos, Paul Van Cruchten, Steven UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
title | UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
title_full | UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
title_fullStr | UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
title_full_unstemmed | UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
title_short | UPLC/MS MS data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
title_sort | uplc/ms ms data of testosterone metabolites in human and zebrafish liver microsomes and whole zebrafish larval microsomes |
topic | Pharmacology, Toxicology and Pharmaceutical Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847491/ https://www.ncbi.nlm.nih.gov/pubmed/29541660 http://dx.doi.org/10.1016/j.dib.2017.11.079 |
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