Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation

The key metabolic sensor adenosine monophosphate-dependent kinase (AMPK) has emerged as a promising therapeutic target for cancer prevention and treatment. Besides its role in energy homeostasis, AMPK blocks cell cycle, regulates autophagy and suppresses the anabolic processes required for rapid cel...

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Detalles Bibliográficos
Autores principales: Bort, Alicia, Quesada, Sergio, Ramos-Torres, Ágata, Gargantilla, Marta, Priego, Eva María, Raynal, Sophie, Lepifre, Franck, Gasalla, Jose M., Rodriguez-Henche, Nieves, Castro, Ana, Díaz-Laviada, Inés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847527/
https://www.ncbi.nlm.nih.gov/pubmed/29531259
http://dx.doi.org/10.1038/s41598-018-22690-2

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