An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients

Neuronal calcium sensor-1 (NCS-1) has been identified as a binding partner of the taxane, paclitaxel. Our previous study showed that overexpression of NCS-1 increased the efficacy of paclitaxel in vitro, but was associated with poor clinical outcome. Here, we determine if NCS-1 expression is associa...

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Autores principales: Moore, Lauren M., Wilkinson, Rachel, Altan, Mehmet, Toki, Maria, Carvajal-Hausdorf, Daniel E., McGuire, John, Ehrlich, Barbara E., Rimm, David L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847580/
https://www.ncbi.nlm.nih.gov/pubmed/29560416
http://dx.doi.org/10.1038/s41523-018-0057-7
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author Moore, Lauren M.
Wilkinson, Rachel
Altan, Mehmet
Toki, Maria
Carvajal-Hausdorf, Daniel E.
McGuire, John
Ehrlich, Barbara E.
Rimm, David L.
author_facet Moore, Lauren M.
Wilkinson, Rachel
Altan, Mehmet
Toki, Maria
Carvajal-Hausdorf, Daniel E.
McGuire, John
Ehrlich, Barbara E.
Rimm, David L.
author_sort Moore, Lauren M.
collection PubMed
description Neuronal calcium sensor-1 (NCS-1) has been identified as a binding partner of the taxane, paclitaxel. Our previous study showed that overexpression of NCS-1 increased the efficacy of paclitaxel in vitro, but was associated with poor clinical outcome. Here, we determine if NCS-1 expression is associated with pathological complete response (pCR) to taxane-based neoadjuvant chemotherapy in 105 pre-treatment breast cancer biopsies. Elevated expression of NCS-1 was found to be positively associated with pCR. These results suggest that NCS-1 may be a predictive biomarker for response to taxane-based neoadjuvant chemotherapy in breast cancer.
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spelling pubmed-58475802018-03-20 An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients Moore, Lauren M. Wilkinson, Rachel Altan, Mehmet Toki, Maria Carvajal-Hausdorf, Daniel E. McGuire, John Ehrlich, Barbara E. Rimm, David L. NPJ Breast Cancer Brief Communication Neuronal calcium sensor-1 (NCS-1) has been identified as a binding partner of the taxane, paclitaxel. Our previous study showed that overexpression of NCS-1 increased the efficacy of paclitaxel in vitro, but was associated with poor clinical outcome. Here, we determine if NCS-1 expression is associated with pathological complete response (pCR) to taxane-based neoadjuvant chemotherapy in 105 pre-treatment breast cancer biopsies. Elevated expression of NCS-1 was found to be positively associated with pCR. These results suggest that NCS-1 may be a predictive biomarker for response to taxane-based neoadjuvant chemotherapy in breast cancer. Nature Publishing Group UK 2018-03-12 /pmc/articles/PMC5847580/ /pubmed/29560416 http://dx.doi.org/10.1038/s41523-018-0057-7 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Moore, Lauren M.
Wilkinson, Rachel
Altan, Mehmet
Toki, Maria
Carvajal-Hausdorf, Daniel E.
McGuire, John
Ehrlich, Barbara E.
Rimm, David L.
An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
title An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
title_full An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
title_fullStr An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
title_full_unstemmed An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
title_short An assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
title_sort assessment of neuronal calcium sensor-1 and response to neoadjuvant chemotherapy in breast cancer patients
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847580/
https://www.ncbi.nlm.nih.gov/pubmed/29560416
http://dx.doi.org/10.1038/s41523-018-0057-7
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