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Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Human leukocyte antigen (HLA)-I molecules generally bind short peptides (8–10 amino acids), although extended HLA-I restricted peptides (>10 amino acids) can be presented to T cells. However, the function of such extended HLA-I epitopes in tumour immunity, and how they would be recognised by T-ce...

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Detalles Bibliográficos
Autores principales: Chan, Kok Fei, Gully, Benjamin S., Gras, Stephanie, Beringer, Dennis X., Kjer-Nielsen, Lars, Cebon, Jonathan, McCluskey, James, Chen, Weisan, Rossjohn, Jamie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847591/
https://www.ncbi.nlm.nih.gov/pubmed/29531227
http://dx.doi.org/10.1038/s41467-018-03321-w