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Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS

Thousands of organohalogen compounds, including hazardous chemicals such as polychlorinated biphenyls (PCBs) and other persistent organic pollutants (POPs), were selectively and simultaneously detected and identified with simple, or no, purification from environmental sample extracts by using severa...

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Autores principales: Hashimoto, Shunji, Zushi, Yasuyuki, Takazawa, Yoshikatsu, Ieda, Teruyo, Fushimi, Akihiro, Tanabe, Kiyoshi, Shibata, Yasuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847631/
https://www.ncbi.nlm.nih.gov/pubmed/26194242
http://dx.doi.org/10.1007/s11356-015-5059-5
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author Hashimoto, Shunji
Zushi, Yasuyuki
Takazawa, Yoshikatsu
Ieda, Teruyo
Fushimi, Akihiro
Tanabe, Kiyoshi
Shibata, Yasuyuki
author_facet Hashimoto, Shunji
Zushi, Yasuyuki
Takazawa, Yoshikatsu
Ieda, Teruyo
Fushimi, Akihiro
Tanabe, Kiyoshi
Shibata, Yasuyuki
author_sort Hashimoto, Shunji
collection PubMed
description Thousands of organohalogen compounds, including hazardous chemicals such as polychlorinated biphenyls (PCBs) and other persistent organic pollutants (POPs), were selectively and simultaneously detected and identified with simple, or no, purification from environmental sample extracts by using several advanced methods. The methods used were software extraction from two-dimensional gas chromatography–high-resolution time-of-flight mass spectrometry (GC × GC–HRTofMS) data, measurement by negative chemical ionization with HRTofMS, and neutral loss scanning (NLS) with GC × GC–MS/MS. Global and selective detection of organochlorines and bromines in environmental samples such as sediments and fly ash was achieved by NLS using GC × GC–MS/MS (QQQ), with the expected losses of (35)Cl and (79)Br. We confirmed that negative chemical ionization was effective for sensitive and selective ionization of organohalogens, even using GC × GC–HRTofMS. The 2D total ion chromatograms obtained by using negative chemical ionization and selective extraction of organohalogens using original software from data measured by electron impact ionization were very similar; the software thus functioned well to extract organohalogens. Combining measurements made by using these different methods will help to detect organohalogens selectively and globally. However, to compare the data obtained by individual measurements, the retention times of the peaks on the 2D chromatograms need to match. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11356-015-5059-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-58476312018-03-20 Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS Hashimoto, Shunji Zushi, Yasuyuki Takazawa, Yoshikatsu Ieda, Teruyo Fushimi, Akihiro Tanabe, Kiyoshi Shibata, Yasuyuki Environ Sci Pollut Res Int Advances in Environmental Chemistry of Pollutants Thousands of organohalogen compounds, including hazardous chemicals such as polychlorinated biphenyls (PCBs) and other persistent organic pollutants (POPs), were selectively and simultaneously detected and identified with simple, or no, purification from environmental sample extracts by using several advanced methods. The methods used were software extraction from two-dimensional gas chromatography–high-resolution time-of-flight mass spectrometry (GC × GC–HRTofMS) data, measurement by negative chemical ionization with HRTofMS, and neutral loss scanning (NLS) with GC × GC–MS/MS. Global and selective detection of organochlorines and bromines in environmental samples such as sediments and fly ash was achieved by NLS using GC × GC–MS/MS (QQQ), with the expected losses of (35)Cl and (79)Br. We confirmed that negative chemical ionization was effective for sensitive and selective ionization of organohalogens, even using GC × GC–HRTofMS. The 2D total ion chromatograms obtained by using negative chemical ionization and selective extraction of organohalogens using original software from data measured by electron impact ionization were very similar; the software thus functioned well to extract organohalogens. Combining measurements made by using these different methods will help to detect organohalogens selectively and globally. However, to compare the data obtained by individual measurements, the retention times of the peaks on the 2D chromatograms need to match. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s11356-015-5059-5) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2015-07-22 2018 /pmc/articles/PMC5847631/ /pubmed/26194242 http://dx.doi.org/10.1007/s11356-015-5059-5 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Advances in Environmental Chemistry of Pollutants
Hashimoto, Shunji
Zushi, Yasuyuki
Takazawa, Yoshikatsu
Ieda, Teruyo
Fushimi, Akihiro
Tanabe, Kiyoshi
Shibata, Yasuyuki
Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS
title Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS
title_full Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS
title_fullStr Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS
title_full_unstemmed Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS
title_short Selective and comprehensive analysis of organohalogen compounds by GC × GC–HRTofMS and MS/MS
title_sort selective and comprehensive analysis of organohalogen compounds by gc × gc–hrtofms and ms/ms
topic Advances in Environmental Chemistry of Pollutants
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847631/
https://www.ncbi.nlm.nih.gov/pubmed/26194242
http://dx.doi.org/10.1007/s11356-015-5059-5
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