Cargando…

Treatment with the mitochondrial‐targeted antioxidant peptide SS‐31 rescues neurovascular coupling responses and cerebrovascular endothelial function and improves cognition in aged mice

Moment‐to‐moment adjustment of cerebral blood flow (CBF) via neurovascular coupling has an essential role in maintenance of healthy cognitive function. In advanced age, increased oxidative stress and cerebromicrovascular endothelial dysfunction impair neurovascular coupling, likely contributing to a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tarantini, Stefano, Valcarcel‐Ares, Noa M., Yabluchanskiy, Andriy, Fulop, Gabor A., Hertelendy, Peter, Gautam, Tripti, Farkas, Eszter, Perz, Aleksandra, Rabinovitch, Peter S., Sonntag, William E., Csiszar, Anna, Ungvari, Zoltan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847870/ https://www.ncbi.nlm.nih.gov/pubmed/29405550 http://dx.doi.org/10.1111/acel.12731

Ejemplares similares

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice
por: Tarantini, Stefano, et al.
Publicado: (2019)

NMN Rescues Endothelial Function and Neurovascular Coupling, Improving Cognitive Function in Aged Mice
por: Tarantini, Stefano, et al.
Publicado: (2020)

IGF‐1 deficiency impairs neurovascular coupling in mice: implications for cerebromicrovascular aging
por: Toth, Peter, et al.
Publicado: (2015)

Insulin‐like growth factor 1 deficiency exacerbates hypertension‐induced cerebral microhemorrhages in mice, mimicking the aging phenotype
por: Tarantini, Stefano, et al.
Publicado: (2017)

The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment
por: Ungvari, Anna, et al.
Publicado: (2023)

Potential Adverse Cardiovascular Effects of Treatment With Fluoxetine and Other Selective Serotonin Reuptake Inhibitors (SSRIs) in Patients With Geriatric Depression: Implications for Atherogenesis and Cerebromicrovascular Dysregulation
por: Ungvari, Zoltan, et al.
Publicado: (2019)

Sleep deprivation impairs cognitive performance, alters task-associated cerebral blood flow and decreases cortical neurovascular coupling-related hemodynamic responses
por: Csipo, Tamas, et al.
Publicado: (2021)

Increased cognitive workload evokes greater neurovascular coupling responses in healthy young adults
por: Csipo, Tamas, et al.
Publicado: (2021)

Fusogenic Liposomes Deliver Resveratrol to Brain Microcirculation and Improve Neurovascular Coupling in Aged Mice
por: Toth, Adam Nyul, et al.
Publicado: (2020)

Insulin-like growth factor-1 in CNS and cerebrovascular aging
por: Sonntag, William E., et al.
Publicado: (2013)

Aging exacerbates hypertension-induced cerebral microhemorrhages in mice: role of resveratrol treatment in vasoprotection
por: Toth, Peter, et al.
Publicado: (2015)

Endothelial Dysfunction and Impaired Neurovascular Coupling Responses Precede Cognitive Impairment in a Mouse Model of Geriatric Sepsis
por: Csipo, Tamas, et al.
Publicado: (2021)

Increased Susceptibility to Cerebral Microhemorrhages Is Associated With Imaging Signs of Microvascular Degeneration in the Retina in an Insulin-Like Growth Factor 1 Deficient Mouse Model of Accelerated Aging
por: Miller, Lauren R., et al.
Publicado: (2022)

Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults
por: Toth, Luca, et al.
Publicado: (2022)

Sleep deprivation alters task‐related changes in functional connectivity of the frontal cortex: A near‐infrared spectroscopy study
por: Mukli, Peter, et al.
Publicado: (2021)

From Geroscience Discoveries to Public Health Practice: Shifting the Paradigm towards Healthy Ageing
por: Csiszar, A, et al.
Publicado: (2023)

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain
por: Ahire, Chetan, et al.
Publicado: (2023)

Exposome and unhealthy aging: environmental drivers from air pollution to occupational exposures
por: Pandics, Tamas, et al.
Publicado: (2023)

Gait variability predicts cognitive impairment in older adults with subclinical cerebral small vessel disease
por: Mukli, Peter, et al.
Publicado: (2022)

The effect of hyperglycemia on neurovascular coupling and cerebrovascular patterning in zebrafish
por: Chhabria, Karishma, et al.
Publicado: (2018)

Hypertension-induced cognitive impairment: from pathophysiology to public health
por: Ungvari, Zoltan, et al.
Publicado: (2021)

Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study
por: Owens, Cameron D., et al.
Publicado: (2023)

Cerebral small vessel disease pathology in COVID-19 patients: A systematic review
por: Owens, Cameron D., et al.
Publicado: (2023)

Imaging retinal microvascular manifestations of carotid artery disease in older adults: from diagnosis of ocular complications to understanding microvascular contributions to cognitive impairment
por: István, Lilla, et al.
Publicado: (2021)

Urinary Biomarkers of Oxidative Stress in Aging: Implications for Prediction of Accelerated Biological Age in Prospective Cohort Studies
por: Mukli, Peter, et al.
Publicado: (2022)

Noninvasive low-level tragus stimulation attenuates inflammation and oxidative stress in acute heart failure
por: Dasari, Tarun, et al.
Publicado: (2023)

Sex differences in brain functional connectivity of hippocampus in mild cognitive impairment
por: Williamson, Jordan, et al.
Publicado: (2022)

20-HETE Enzymes and Receptors in the Neurovascular Unit: Implications in Cerebrovascular Disease
por: Gonzalez-Fernandez, Ezekiel, et al.
Publicado: (2020)

Cerebrovascular Reactivity and Neurovascular Coupling in Multiple Sclerosis—A Systematic Review
por: Vestergaard, Mark B., et al.
Publicado: (2022)

Delivery of the Radionuclide (131)I Using Cationic Fusogenic Liposomes as Nanocarriers
por: Kolašinac, Rejhana, et al.
Publicado: (2021)

Neurovascular Coupling Is Impaired in Hypertensive and Diabetic Subjects Without Symptomatic Cerebrovascular Disease
por: Monteiro, Ana, et al.
Publicado: (2021)

Editorial: The Neurovascular Unit as a Potential Biomarker and Therapeutic Target in Cerebrovascular Disease
por: Nizari, Shereen, et al.
Publicado: (2022)

Neurovascular crosstalk and cerebrovascular alterations: an underestimated therapeutic target in autism spectrum disorders
por: Wang, Yiran, et al.
Publicado: (2023)

Cerebrovascular responses to graded exercise in young healthy males and females
por: Ashley, John D., et al.
Publicado: (2020)

Resveratrol Preserves Cerebrovascular Density and Cognitive Function in Aging Mice
por: Oomen, Charlotte A., et al.
Publicado: (2009)

Retinal biomarkers for Alzheimer’s disease and vascular cognitive impairment and dementia (VCID): implication for early diagnosis and prognosis
por: Czakó, Cecilia, et al.
Publicado: (2020)

Nrf2 deficiency exacerbates age-related contractile dysfunction and loss of skeletal muscle mass
por: Ahn, Bumsoo, et al.
Publicado: (2018)

Influence of CO(2) on neurovascular coupling: interaction with dynamic cerebral autoregulation and cerebrovascular reactivity
por: Maggio, Paola, et al.
Publicado: (2014)

Animal reservoirs of SARS-CoV-2: calculable COVID-19 risk for older adults from animal to human transmission
por: Valencak, Teresa G., et al.
Publicado: (2021)

Demonstration Of Age-Related Increase In Blood-Brain Barrier Permeability By Longitudinal Intravital Microscopy
por: Toth, Adam Nyul, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_69tvob9q6nefdc7mf0lhgmc23l