Cargando…
Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease
Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potenti...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848059/ https://www.ncbi.nlm.nih.gov/pubmed/29682494 http://dx.doi.org/10.1155/2018/9638797 |
_version_ | 1783305819286142976 |
---|---|
author | Filipović, Branka Marković, Olivera Đurić, Vesna Filipović, Branislav |
author_facet | Filipović, Branka Marković, Olivera Đurić, Vesna Filipović, Branislav |
author_sort | Filipović, Branka |
collection | PubMed |
description | Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state. So we compared findings in 40 NAFLD positive and 36 NAFLD negative patients and correlated their brain tissue volumes with the results of Montreal Cognitive Assessment (MoCA) test. Binomial logistic regression verified the influence of NAFLD state leading to lower cognitive potentials: odds ratio 0.096; 95% confidence interval (CI) 0.032–0.289; p < 0.001. Patients with NAFLD had a greater risk to suffer from the cognitive impairment and depression: RR = 3.9; 95% CI 1.815–8.381; p = 0.0005 and RR = 1.65; 95% CI 1.16–2.36; p = 0.006. NAFLD significantly influenced the cognitive deficit and tissue volume reduction and patients suffering from NAFLD had about four times higher risk of having a cognitive impairment. |
format | Online Article Text |
id | pubmed-5848059 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58480592018-04-22 Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease Filipović, Branka Marković, Olivera Đurić, Vesna Filipović, Branislav Can J Gastroenterol Hepatol Research Article Studies of psychological condition of patients suffering from nonalcoholic fatty liver disease are rather equivocal about the results: while some claim that NAFLD patients suffer from anxiety and depression more than non-NAFLD controls, others do not withstand those findings. Lower cognitive potentials have also been reported, both in patient related and in animal model-based investigations, and correlated with assessed brain tissue changes. We hypothesized that NAFLD, as a condition, affects the brain tissue and, subsequently, the cognitive state. So we compared findings in 40 NAFLD positive and 36 NAFLD negative patients and correlated their brain tissue volumes with the results of Montreal Cognitive Assessment (MoCA) test. Binomial logistic regression verified the influence of NAFLD state leading to lower cognitive potentials: odds ratio 0.096; 95% confidence interval (CI) 0.032–0.289; p < 0.001. Patients with NAFLD had a greater risk to suffer from the cognitive impairment and depression: RR = 3.9; 95% CI 1.815–8.381; p = 0.0005 and RR = 1.65; 95% CI 1.16–2.36; p = 0.006. NAFLD significantly influenced the cognitive deficit and tissue volume reduction and patients suffering from NAFLD had about four times higher risk of having a cognitive impairment. Hindawi 2018-02-27 /pmc/articles/PMC5848059/ /pubmed/29682494 http://dx.doi.org/10.1155/2018/9638797 Text en Copyright © 2018 Branka Filipović et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Filipović, Branka Marković, Olivera Đurić, Vesna Filipović, Branislav Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
title | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
title_full | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
title_fullStr | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
title_full_unstemmed | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
title_short | Cognitive Changes and Brain Volume Reduction in Patients with Nonalcoholic Fatty Liver Disease |
title_sort | cognitive changes and brain volume reduction in patients with nonalcoholic fatty liver disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848059/ https://www.ncbi.nlm.nih.gov/pubmed/29682494 http://dx.doi.org/10.1155/2018/9638797 |
work_keys_str_mv | AT filipovicbranka cognitivechangesandbrainvolumereductioninpatientswithnonalcoholicfattyliverdisease AT markovicolivera cognitivechangesandbrainvolumereductioninpatientswithnonalcoholicfattyliverdisease AT đuricvesna cognitivechangesandbrainvolumereductioninpatientswithnonalcoholicfattyliverdisease AT filipovicbranislav cognitivechangesandbrainvolumereductioninpatientswithnonalcoholicfattyliverdisease |