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Selective Closed-State Nav1.7 Blocker JZTX-34 Exhibits Analgesic Effects against Pain

Jingzhaotoxin-34 (JZTX-34) is a selective inhibitor of tetrodotoxin-sensitive (TTX-S) sodium channels. In this study, we found that JZTX-34 selectively acted on Nav1.7 with little effect on other sodium channel subtypes including Nav1.5. If the DIIS3-S4 linker of Nav1.5 is substituted by the corresp...

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Detalles Bibliográficos
Autores principales:	Zeng, Xiongzhi, Li, Pengpeng, Chen, Bo, Huang, Juan, Lai, Ren, Liu, Jingze, Rong, Mingqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848165/ https://www.ncbi.nlm.nih.gov/pubmed/29393892 http://dx.doi.org/10.3390/toxins10020064

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