Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post–kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection...

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Detalles Bibliográficos
Autores principales: Molina, Ricardo, Ghosh, Debashis, Carrillo, Eugenia, Monnerat, Séverine, Bern, Caryn, Mondal, Dinesh, Alvar, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Brief Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848257/
https://www.ncbi.nlm.nih.gov/pubmed/28520851
http://dx.doi.org/10.1093/cid/cix245
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author Molina, Ricardo
Ghosh, Debashis
Carrillo, Eugenia
Monnerat, Séverine
Bern, Caryn
Mondal, Dinesh
Alvar, Jorge
author_facet Molina, Ricardo
Ghosh, Debashis
Carrillo, Eugenia
Monnerat, Séverine
Bern, Caryn
Mondal, Dinesh
Alvar, Jorge
author_sort Molina, Ricardo
collection PubMed
description We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post–kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.
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spelling pubmed-58482572018-03-21 Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent Molina, Ricardo Ghosh, Debashis Carrillo, Eugenia Monnerat, Séverine Bern, Caryn Mondal, Dinesh Alvar, Jorge Clin Infect Dis Brief Reports We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post–kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program. Oxford University Press 2017-07-01 2017-05-18 /pmc/articles/PMC5848257/ /pubmed/28520851 http://dx.doi.org/10.1093/cid/cix245 Text en © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Reports
Molina, Ricardo
Ghosh, Debashis
Carrillo, Eugenia
Monnerat, Séverine
Bern, Caryn
Mondal, Dinesh
Alvar, Jorge
Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
title Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
title_full Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
title_fullStr Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
title_full_unstemmed Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
title_short Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent
title_sort infectivity of post-kala-azar dermal leishmaniasis patients to sand flies: revisiting a proof of concept in the context of the kala-azar elimination program in the indian subcontinent
topic Brief Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848257/
https://www.ncbi.nlm.nih.gov/pubmed/28520851
http://dx.doi.org/10.1093/cid/cix245
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