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Inhibition of CREB binding protein-beta-catenin signaling down regulates CD133 expression and activates PP2A-PTEN signaling in tumor initiating liver cancer cells

BACKGROUND: The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances its nuclear translocation. Nuclear beta-catenin function is regulated by transcr...

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Detalles Bibliográficos
Autores principales:	Tang, Yuanyuan, Berlind, Joshua, Mavila, Nirmala
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848530/ https://www.ncbi.nlm.nih.gov/pubmed/29530069 http://dx.doi.org/10.1186/s12964-018-0222-5

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