Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a clinically and histopathologically heterogeneous neurodegenerative disorder, in which therapy is hindered by the rapid progression of disease and lack of biomarkers. Magnetic resonance imaging (MRI) has demonstrated its potential for detecting the...

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Detalles Bibliográficos
Autores principales: Pallebage-Gamarallage, Menuka, Foxley, Sean, Menke, Ricarda A. L., Huszar, Istvan N., Jenkinson, Mark, Tendler, Benjamin C., Wang, Chaoyue, Jbabdi, Saad, Turner, Martin R., Miller, Karla L., Ansorge, Olaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848544/
https://www.ncbi.nlm.nih.gov/pubmed/29529995
http://dx.doi.org/10.1186/s12868-018-0416-1

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