Novel smac mimetic APG-1387 elicits ovarian cancer cell killing through TNF-alpha, Ripoptosome and autophagy mediated cell death pathway

BACKGROUND: Ovarian cancer is a deadly disease. Inhibitors of apoptosis proteins (IAPs) are key regulators of apoptosis and are frequently dysregulated in ovarian cancer. Overexpression of IAPs proteins has been correlated with tumorigenesis, treatment resistance and poor prognosis. Reinstalling fun...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Bao-Xia, Wang, Heng-Bang, Qiu, Miao-Zhen, Luo, Qiu-Yun, Yi, Han-Jie, Yan, Xiang-Lei, Pan, Wen-Tao, Yuan, Lu-Ping, Zhang, Yu-Xin, Xu, Jian-Hua, Zhang, Lin, Yang, Da-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848599/
https://www.ncbi.nlm.nih.gov/pubmed/29530056
http://dx.doi.org/10.1186/s13046-018-0703-9

Ejemplares similares

Ejemplares similares