Cargando…

Targeting mutant KRAS with CRISPR-Cas9 controls tumor growth

KRAS is the most frequently mutated oncogene in human tumors, and its activating mutations represent important therapeutic targets. The combination of Cas9 and guide RNA from the CRISPR-Cas system recognizes a specific DNA sequence and makes a double-strand break, which enables editing of the releva...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Wonjoo, Lee, Sangeun, Kim, Han Sang, Song, Minjung, Cha, Yong Hoon, Kim, Young-Hoon, Shin, Jeonghong, Lee, Eun-Seo, Joo, Yeonsoo, Song, Jae J., Choi, Eun Ju, Choi, Jae W., Lee, Jinu, Kang, Moonkyung, Yook, Jong In, Lee, Min Goo, Kim, Yeon-Soo, Paik, Soonmyung, Kim, Hyongbum (Henry)
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2018
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848616/ https://www.ncbi.nlm.nih.gov/pubmed/29326299 http://dx.doi.org/10.1101/gr.223891.117

Ejemplares similares

DNA double-strand break-free CRISPR interference delays Huntington’s disease progression in mice
por: Seo, Jung Hwa, et al.
Publicado: (2023)

Hyperpolarized [1-(13)C]pyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice
por: Choi, Young-Suk, et al.
Publicado: (2023)

Active Compound of Pharbitis Semen (Pharbitis nil Seeds) Suppressed KRAS-Driven Colorectal Cancer and Restored Muscle Cell Function during Cancer Progression
por: Song, Jisu, et al.
Publicado: (2020)

Hyperpolarized [1-13C]lactate flux increased in the hippocampal region in diabetic mice
por: Choi, Young-Suk, et al.
Publicado: (2019)

Mutation of GmIPK1 Gene Using CRISPR/Cas9 Reduced Phytic Acid Content in Soybean Seeds
por: Song, Ji Hyeon, et al.
Publicado: (2022)

Differences between immunodeficient mice generated by classical gene targeting and CRISPR/Cas9-mediated gene knockout
por: Lee, Jae Hoon, et al.
Publicado: (2018)

A Therapeutic Strategy for Chemotherapy-Resistant Gastric Cancer via Destabilization of Both β-Catenin and RAS
por: Ryu, Won-Ji, et al.
Publicado: (2019)

Directed evolution of CRISPR-Cas9 to increase its specificity
por: Lee, Jungjoon K., et al.
Publicado: (2018)

SpCas9 activity prediction by DeepSpCas9, a deep learning–based model with high generalization performance
por: Kim, Hui Kwon, et al.
Publicado: (2019)

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis
por: Kim, Dae Gyu, et al.
Publicado: (2022)

Predictive Value of Estimated Lean Body Mass for Neurological Outcomes after Out-of-Hospital Cardiac Arrest †
por: Lee, Sung Eun, et al.
Publicado: (2020)

Generation of lung cancer cell lines harboring EGFR T790M mutation by CRISPR/Cas9-mediated genome editing
por: Park, Mi-Young, et al.
Publicado: (2017)

Influence of Low Peak Respiratory Exchange Ratio on Cardiac Rehabilitation in Patients With Coronary Artery Disease
por: Kim, Chul, et al.
Publicado: (2016)

In vivo delivery of CRISPR-Cas9 using lipid nanoparticles enables antithrombin gene editing for sustainable hemophilia A and B therapy
por: Han, Jeong Pil, et al.
Publicado: (2022)

Earlier-Phased Cancer Immunity Cycle Strongly Influences Cancer Immunity in Operable Never-Smoker Lung Adenocarcinoma
por: Kim, Hong Kwan, et al.
Publicado: (2020)

TSA Promotes CRISPR/Cas9 Editing Efficiency and Expression of Cell Division-Related Genes from Plant Protoplasts
por: Choi, Seung Hee, et al.
Publicado: (2021)

Sniper2L is a high-fidelity Cas9 variant with high activity
por: Kim, Young-hoon, et al.
Publicado: (2023)

Rh D blood group conversion using transcription activator-like effector nucleases
por: Kim, Young-Hoon, et al.
Publicado: (2015)

Corrigendum: Rh D blood group conversion using transcription activator-like effector nucleases
por: Kim, Young-Hoon, et al.
Publicado: (2015)

CRISPR/Cas-based customization of pooled CRISPR libraries
por: Kweon, Jiyeon, et al.
Publicado: (2018)

Hyperpolarized [1-13C] pyruvate MR spectroscopy detect altered glycolysis in the brain of a cognitively impaired mouse model fed high-fat diet
por: Choi, Young-Suk, et al.
Publicado: (2018)

Genome Editing Using CRISPR-Cas9 and Autoimmune Diseases: A Comprehensive Review
por: Lee, Min Ho, et al.
Publicado: (2022)

Identification of somatic mutations in EGFR/KRAS/ALK-negative lung adenocarcinoma in never-smokers
por: Ahn, Jin Woo, et al.
Publicado: (2014)

Basic Principles and Clinical Applications of CRISPR-Based Genome Editing
por: Lim, Jung Min, et al.
Publicado: (2022)

Direct observation of DNA target searching and cleavage by CRISPR-Cas12a
por: Jeon, Yongmoon, et al.
Publicado: (2018)

Highly Efficient DNA Reporter for CRISPR/Cas12a-Based Specific and Sensitive Biosensor
por: Lee, Seungjin, et al.
Publicado: (2022)

Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
por: Paik, Soonmyung, et al.
Publicado: (2021)

Phellinus linteus Grown on Germinated Brown Rice Increases Cetuximab Sensitivity of KRAS-Mutated Colon Cancer
por: Park, Hye-Jin, et al.
Publicado: (2017)

The impact of shift and night work on health related quality of life of working women: findings from the Korea Health Panel
por: Kim, Woorim, et al.
Publicado: (2016)

Impacts of Irradiation Sources on Quality Attributes of Low-salt Sausage during Refrigerated Storage
por: Song, Dong-Heon, et al.
Publicado: (2017)

CRISPR/Cas9-Mediated HY5 Gene Editing Reduces Growth Inhibition in Chinese Cabbage (Brassica rapa) under ER Stress
por: Lee, Ye Rin, et al.
Publicado: (2023)

Impaired AKT signaling and lung tumorigenesis by PIERCE1 ablation in KRAS-mutant non-small cell lung cancer
por: Roh, Jae-il, et al.
Publicado: (2020)

Prevalence and clinical characterization of BRCA1 and BRCA2 mutations in Korean patients with epithelial ovarian cancer
por: Paik, E Sun, et al.
Publicado: (2021)

Fas mutation reduces obesity by increasing IL-4 and IL-10 expression and promoting white adipose tissue browning
por: Choi, Eun Wha, et al.
Publicado: (2020)

Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans
por: Lee, Eun Byeol, et al.
Publicado: (2015)

Different metastatic pattern according to the KRAS mutational status and site-specific discordance of KRAS status in patients with colorectal cancer
por: Kim, Mi-Jung, et al.
Publicado: (2012)

PIK3CA Amplification Is Common in Left Side-Tubular Adenomas but Uncommon Sessile Serrated Adenomas Exclusively with KRAS Mutation
por: Lee, Hyunsu, et al.
Publicado: (2015)

Multiple sgRNAs with overlapping sequences enhance CRISPR/Cas9-mediated knock-in efficiency
por: Jang, Da Eun, et al.
Publicado: (2018)

Selective targeting of KRAS oncogenic alleles by CRISPR/Cas9 inhibits proliferation of cancer cells
por: Lee, Wookjae, et al.
Publicado: (2018)

Implementation of ubiquitous chromatin opening elements as artificial integration sites for CRISPR/Cas9‐mediated knock‐in in mammalian cells
por: Kim, Seul Mi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ogb5hga396s0450s0pckfehal9