Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor developmen...

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Detalles Bibliográficos
Autores principales: Whipple, Chery A., Lander, Arthur D., Korc, Murray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2008
Materias:
Directions in Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848622/
https://www.ncbi.nlm.nih.gov/pubmed/19082421
http://dx.doi.org/10.1100/tsw.2008.152
Descripción
Sumario:The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.

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