Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor developmen...

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Detalles Bibliográficos
Autores principales: Whipple, Chery A., Lander, Arthur D., Korc, Murray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2008
Materias:
Directions in Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848622/
https://www.ncbi.nlm.nih.gov/pubmed/19082421
http://dx.doi.org/10.1100/tsw.2008.152
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author Whipple, Chery A.
Lander, Arthur D.
Korc, Murray
author_facet Whipple, Chery A.
Lander, Arthur D.
Korc, Murray
author_sort Whipple, Chery A.
collection PubMed
description The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer.
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spelling pubmed-58486222018-04-17 Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis Whipple, Chery A. Lander, Arthur D. Korc, Murray ScientificWorldJournal Directions in Science The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice. Interestingly, both cancer cell–derived and host-derived GPC1 play an important role in tumor development and spread. These data suggest that GPC1 may be a valid therapeutic target for pancreatic cancer. TheScientificWorldJOURNAL 2008-12-14 /pmc/articles/PMC5848622/ /pubmed/19082421 http://dx.doi.org/10.1100/tsw.2008.152 Text en Copyright © 2008 Chery A. Whipple et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Directions in Science
Whipple, Chery A.
Lander, Arthur D.
Korc, Murray
Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
title Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
title_full Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
title_fullStr Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
title_full_unstemmed Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
title_short Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis
title_sort discovery of a novel molecule that regulates tumor growth and metastasis
topic Directions in Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848622/
https://www.ncbi.nlm.nih.gov/pubmed/19082421
http://dx.doi.org/10.1100/tsw.2008.152
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