Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives

A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obta...

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Detalles Bibliográficos
Autores principales: Coimbra, Elaine S., Almeida, Camila G., Júnior, Wilson V., Dos Reis, Roberta C. N., De Almeida, Ana C. F., Forezi, Luana S. M., De Almeida, Mauro V., Le Hyaric, Mireille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848739/
https://www.ncbi.nlm.nih.gov/pubmed/18677429
http://dx.doi.org/10.1100/tsw.2008.100
Descripción
Sumario:A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC(50) against L. chagasi below 5 μM.

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