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Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives
A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obta...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
TheScientificWorldJOURNAL
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848739/ https://www.ncbi.nlm.nih.gov/pubmed/18677429 http://dx.doi.org/10.1100/tsw.2008.100 |
| _version_ | 1783305930561028096 |
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| author | Coimbra, Elaine S. Almeida, Camila G. Júnior, Wilson V. Dos Reis, Roberta C. N. De Almeida, Ana C. F. Forezi, Luana S. M. De Almeida, Mauro V. Le Hyaric, Mireille |
| author_facet | Coimbra, Elaine S. Almeida, Camila G. Júnior, Wilson V. Dos Reis, Roberta C. N. De Almeida, Ana C. F. Forezi, Luana S. M. De Almeida, Mauro V. Le Hyaric, Mireille |
| author_sort | Coimbra, Elaine S. |
| collection | PubMed |
| description | A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC(50) against L. chagasi below 5 μM. |
| format | Online Article Text |
| id | pubmed-5848739 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | TheScientificWorldJOURNAL |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-58487392018-04-17 Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives Coimbra, Elaine S. Almeida, Camila G. Júnior, Wilson V. Dos Reis, Roberta C. N. De Almeida, Ana C. F. Forezi, Luana S. M. De Almeida, Mauro V. Le Hyaric, Mireille ScientificWorldJournal Research Article A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC(50) against L. chagasi below 5 μM. TheScientificWorldJOURNAL 2008-07-31 /pmc/articles/PMC5848739/ /pubmed/18677429 http://dx.doi.org/10.1100/tsw.2008.100 Text en Copyright © 2008 Elaine S. Coimbra et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Coimbra, Elaine S. Almeida, Camila G. Júnior, Wilson V. Dos Reis, Roberta C. N. De Almeida, Ana C. F. Forezi, Luana S. M. De Almeida, Mauro V. Le Hyaric, Mireille Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_full | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_fullStr | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_full_unstemmed | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_short | Antileishmanial Activity of Aldonamides and N-Acyl-Diamine Derivatives |
| title_sort | antileishmanial activity of aldonamides and n-acyl-diamine derivatives |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848739/ https://www.ncbi.nlm.nih.gov/pubmed/18677429 http://dx.doi.org/10.1100/tsw.2008.100 |
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