Heat Shock Proteins and Neurodegenerative Disorders

Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summ...

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Detalles Bibliográficos
Autores principales: Soo, Eliza Ting-Li, Ng, Yee-Kong, Bay, Boon-Huat, Yip, George Wai-Cheong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2008
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848761/
https://www.ncbi.nlm.nih.gov/pubmed/18661049
http://dx.doi.org/10.1100/tsw.2008.48
Descripción
Sumario:Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion disease.

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