Heat Shock Proteins and Neurodegenerative Disorders

Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summ...

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Detalles Bibliográficos
Autores principales: Soo, Eliza Ting-Li, Ng, Yee-Kong, Bay, Boon-Huat, Yip, George Wai-Cheong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: TheScientificWorldJOURNAL 2008
Materias:
Mini-Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848761/
https://www.ncbi.nlm.nih.gov/pubmed/18661049
http://dx.doi.org/10.1100/tsw.2008.48
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author Soo, Eliza Ting-Li
Ng, Yee-Kong
Bay, Boon-Huat
Yip, George Wai-Cheong
author_facet Soo, Eliza Ting-Li
Ng, Yee-Kong
Bay, Boon-Huat
Yip, George Wai-Cheong
author_sort Soo, Eliza Ting-Li
collection PubMed
description Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion disease.
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spelling pubmed-58487612018-04-17 Heat Shock Proteins and Neurodegenerative Disorders Soo, Eliza Ting-Li Ng, Yee-Kong Bay, Boon-Huat Yip, George Wai-Cheong ScientificWorldJournal Mini-Review Heat shock proteins (HSPs) are evolutionarily conserved molecules and play important roles in fundamental cellular processes. They serve as molecular chaperones and hence provide a protective function in ensuring cell survival and repair of cellular damage after a stressful stimulus. This paper summarizes the current knowledge about the different roles of HSPs in aging and disease, focusing on the neurodegenerative disorders of Alzheimer's disease, Parkinson's disease, Huntington's disease, and prion disease. TheScientificWorldJOURNAL 2008-03-03 /pmc/articles/PMC5848761/ /pubmed/18661049 http://dx.doi.org/10.1100/tsw.2008.48 Text en Copyright © 2008 Eliza Ting-Li Soo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Mini-Review
Soo, Eliza Ting-Li
Ng, Yee-Kong
Bay, Boon-Huat
Yip, George Wai-Cheong
Heat Shock Proteins and Neurodegenerative Disorders
title Heat Shock Proteins and Neurodegenerative Disorders
title_full Heat Shock Proteins and Neurodegenerative Disorders
title_fullStr Heat Shock Proteins and Neurodegenerative Disorders
title_full_unstemmed Heat Shock Proteins and Neurodegenerative Disorders
title_short Heat Shock Proteins and Neurodegenerative Disorders
title_sort heat shock proteins and neurodegenerative disorders
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848761/
https://www.ncbi.nlm.nih.gov/pubmed/18661049
http://dx.doi.org/10.1100/tsw.2008.48
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