PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer

Development of resistance causes failure of drugs targeting receptor tyrosine kinase (RTK) networks and represents a critical challenge for precision medicine. Here, we show that PHLDA1 downregulation is critical to acquisition and maintenance of drug resistance in RTK-driven cancer. Using fibroblas...

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Detalles Bibliográficos
Autores principales: Fearon, Abbie E., Carter, Edward P., Clayton, Natasha S., Wilkes, Edmund H., Baker, Ann-Marie, Kapitonova, Ekaterina, Bakhouche, Bakhouche A., Tanner, Yasmine, Wang, Jun, Gadaleta, Emanuela, Chelala, Claude, Moore, Kate M., Marshall, John F., Chupin, Juliette, Schmid, Peter, Jones, J. Louise, Lockley, Michelle, Cutillas, Pedro R., Grose, Richard P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5848852/
https://www.ncbi.nlm.nih.gov/pubmed/29490281
http://dx.doi.org/10.1016/j.celrep.2018.02.028

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