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Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties

Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological...

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Autores principales: Reichert, Aline, Seidenstuecker, Michael, Gadow, Rainer, Mayr, Hermann O., Suedkamp, Norbert P., Latorre, Sergio H., Weichand, Partick, Bernstein, Anke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849013/
https://www.ncbi.nlm.nih.gov/pubmed/29470416
http://dx.doi.org/10.3390/ma11020316
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author Reichert, Aline
Seidenstuecker, Michael
Gadow, Rainer
Mayr, Hermann O.
Suedkamp, Norbert P.
Latorre, Sergio H.
Weichand, Partick
Bernstein, Anke
author_facet Reichert, Aline
Seidenstuecker, Michael
Gadow, Rainer
Mayr, Hermann O.
Suedkamp, Norbert P.
Latorre, Sergio H.
Weichand, Partick
Bernstein, Anke
author_sort Reichert, Aline
collection PubMed
description Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine. The aim of this investigation was to test the suitability of C/SiSiC ceramics as a new material for bearing couples in endoprosthetics. After the preparation of the composites flexural strength was determined as well as the Young’s-modulus and the coefficient of friction. To investigate in vitro biological properties, MG 63 and primary human osteoblasts were cultured on C/SiSiC composites. To review the proliferation, the cytotoxicity standardized tests were used. The cell morphology was observed by light microscopy, ESEM, confocal and 3D-laserscanning microscopy. C/SiSiC possesses a high resistance to wear. Cells exhibited no significant alterations in morphology. Vitality was not impaired by contact with the ceramic composite. There was no higher cytotoxicity to observe. Regarding these results, C/SiSiC ceramics seem to be biologically and mechanically appropriate for orthopaedic applications.
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spelling pubmed-58490132018-03-14 Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties Reichert, Aline Seidenstuecker, Michael Gadow, Rainer Mayr, Hermann O. Suedkamp, Norbert P. Latorre, Sergio H. Weichand, Partick Bernstein, Anke Materials (Basel) Article Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction/lubrication/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine. The aim of this investigation was to test the suitability of C/SiSiC ceramics as a new material for bearing couples in endoprosthetics. After the preparation of the composites flexural strength was determined as well as the Young’s-modulus and the coefficient of friction. To investigate in vitro biological properties, MG 63 and primary human osteoblasts were cultured on C/SiSiC composites. To review the proliferation, the cytotoxicity standardized tests were used. The cell morphology was observed by light microscopy, ESEM, confocal and 3D-laserscanning microscopy. C/SiSiC possesses a high resistance to wear. Cells exhibited no significant alterations in morphology. Vitality was not impaired by contact with the ceramic composite. There was no higher cytotoxicity to observe. Regarding these results, C/SiSiC ceramics seem to be biologically and mechanically appropriate for orthopaedic applications. MDPI 2018-02-22 /pmc/articles/PMC5849013/ /pubmed/29470416 http://dx.doi.org/10.3390/ma11020316 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Reichert, Aline
Seidenstuecker, Michael
Gadow, Rainer
Mayr, Hermann O.
Suedkamp, Norbert P.
Latorre, Sergio H.
Weichand, Partick
Bernstein, Anke
Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties
title Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties
title_full Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties
title_fullStr Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties
title_full_unstemmed Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties
title_short Carbon-Fibre-Reinforced SiC Composite (C/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties
title_sort carbon-fibre-reinforced sic composite (c/sisic) as an alternative material for endoprosthesis: fabrication, mechanical and in-vitro biological properties
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849013/
https://www.ncbi.nlm.nih.gov/pubmed/29470416
http://dx.doi.org/10.3390/ma11020316
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