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Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus

In a recent report, the World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health, food security, and development. Methicillin-resistant Staphylococcus aureus (MRSA) remains at the core of this threat, with persistent and resilient strains detec...

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Detalles Bibliográficos
Autores principales: Hibbitts, Alan, O’Leary, Cian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849018/
https://www.ncbi.nlm.nih.gov/pubmed/29473883
http://dx.doi.org/10.3390/ma11020321
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author Hibbitts, Alan
O’Leary, Cian
author_facet Hibbitts, Alan
O’Leary, Cian
author_sort Hibbitts, Alan
collection PubMed
description In a recent report, the World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health, food security, and development. Methicillin-resistant Staphylococcus aureus (MRSA) remains at the core of this threat, with persistent and resilient strains detectable in up to 90% of S. aureus infections. Unfortunately, there is a lack of novel antibiotics reaching the clinic to address the significant morbidity and mortality that MRSA is responsible for. Recently, nanomedicine strategies have emerged as a promising therapy to combat the rise of MRSA. However, these approaches have been wide-ranging in design, with few attempts to compare studies across scientific and clinical disciplines. This review seeks to reconcile this discrepancy in the literature, with specific focus on the mechanisms of MRSA infection and how they can be exploited by bioactive molecules that are delivered by nanomedicines, in addition to utilisation of the nanomaterials themselves as antibacterial agents. Finally, we discuss targeting MRSA biofilms using nano-patterning technologies and comment on future opportunities and challenges for MRSA treatment using nanomedicine.
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spelling pubmed-58490182018-03-14 Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus Hibbitts, Alan O’Leary, Cian Materials (Basel) Review In a recent report, the World Health Organisation (WHO) classified antibiotic resistance as one of the greatest threats to global health, food security, and development. Methicillin-resistant Staphylococcus aureus (MRSA) remains at the core of this threat, with persistent and resilient strains detectable in up to 90% of S. aureus infections. Unfortunately, there is a lack of novel antibiotics reaching the clinic to address the significant morbidity and mortality that MRSA is responsible for. Recently, nanomedicine strategies have emerged as a promising therapy to combat the rise of MRSA. However, these approaches have been wide-ranging in design, with few attempts to compare studies across scientific and clinical disciplines. This review seeks to reconcile this discrepancy in the literature, with specific focus on the mechanisms of MRSA infection and how they can be exploited by bioactive molecules that are delivered by nanomedicines, in addition to utilisation of the nanomaterials themselves as antibacterial agents. Finally, we discuss targeting MRSA biofilms using nano-patterning technologies and comment on future opportunities and challenges for MRSA treatment using nanomedicine. MDPI 2018-02-23 /pmc/articles/PMC5849018/ /pubmed/29473883 http://dx.doi.org/10.3390/ma11020321 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hibbitts, Alan
O’Leary, Cian
Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
title Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
title_full Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
title_fullStr Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
title_full_unstemmed Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
title_short Emerging Nanomedicine Therapies to Counter the Rise of Methicillin-Resistant Staphylococcus aureus
title_sort emerging nanomedicine therapies to counter the rise of methicillin-resistant staphylococcus aureus
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849018/
https://www.ncbi.nlm.nih.gov/pubmed/29473883
http://dx.doi.org/10.3390/ma11020321
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