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3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil

In this work, a three dimensional (3D) graphene-nitrogen doped carbon nanotubes (G-NCNTs) network was successfully fabricated on the surface of a glassy carbon (GC) electrode using the pulse potential method (PPM) in a graphene oxide-nitrogen doped carbon nanotubes (GO-NCNTs) dispersion. The morphol...

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Autores principales: Wu, Yanju, Zhou, Anxing, Yang, Huimin, Wang, Fei, Lu, Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849019/
https://www.ncbi.nlm.nih.gov/pubmed/29473881
http://dx.doi.org/10.3390/ma11020322
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author Wu, Yanju
Zhou, Anxing
Yang, Huimin
Wang, Fei
Lu, Kui
author_facet Wu, Yanju
Zhou, Anxing
Yang, Huimin
Wang, Fei
Lu, Kui
author_sort Wu, Yanju
collection PubMed
description In this work, a three dimensional (3D) graphene-nitrogen doped carbon nanotubes (G-NCNTs) network was successfully fabricated on the surface of a glassy carbon (GC) electrode using the pulse potential method (PPM) in a graphene oxide-nitrogen doped carbon nanotubes (GO-NCNTs) dispersion. The morphological and characteristics of GO-NCNTs and G-NCNTs nanocomposites were investigated by atomic force microscopy (AFM), scanning electron microscopy (SEM), UV-vis spectroscopy, Raman spectroscopy, and electrochemical experiments. The 3DG-NCNTs network was applied as a new voltammetric material for the fabrication of an electrochemical platform for determination of urapidil. Systematic electrochemical tests demonstrate that the 3DG-NCNTs network modified GC electrode can effectively increase the response to the oxidation of urapidil. Under the optimum conditions, the electrochemical response was linear with urapidil concentrations in the range of 1.0 × 10(−8)~2.0 × 10(−6) mol·L(−1), while a low detection limit of 5.0 × 10(−9) mol·L(−1) was obtained for urapidil. Moreover, the proposed sensing platform exhibited good results for sensitivity, reproducibility, selectivity, and stability, which makes it very suitable for use as an ideal inexpensive and rapid analytical method applicable for complex drug matrices.
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spelling pubmed-58490192018-03-14 3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil Wu, Yanju Zhou, Anxing Yang, Huimin Wang, Fei Lu, Kui Materials (Basel) Article In this work, a three dimensional (3D) graphene-nitrogen doped carbon nanotubes (G-NCNTs) network was successfully fabricated on the surface of a glassy carbon (GC) electrode using the pulse potential method (PPM) in a graphene oxide-nitrogen doped carbon nanotubes (GO-NCNTs) dispersion. The morphological and characteristics of GO-NCNTs and G-NCNTs nanocomposites were investigated by atomic force microscopy (AFM), scanning electron microscopy (SEM), UV-vis spectroscopy, Raman spectroscopy, and electrochemical experiments. The 3DG-NCNTs network was applied as a new voltammetric material for the fabrication of an electrochemical platform for determination of urapidil. Systematic electrochemical tests demonstrate that the 3DG-NCNTs network modified GC electrode can effectively increase the response to the oxidation of urapidil. Under the optimum conditions, the electrochemical response was linear with urapidil concentrations in the range of 1.0 × 10(−8)~2.0 × 10(−6) mol·L(−1), while a low detection limit of 5.0 × 10(−9) mol·L(−1) was obtained for urapidil. Moreover, the proposed sensing platform exhibited good results for sensitivity, reproducibility, selectivity, and stability, which makes it very suitable for use as an ideal inexpensive and rapid analytical method applicable for complex drug matrices. MDPI 2018-02-23 /pmc/articles/PMC5849019/ /pubmed/29473881 http://dx.doi.org/10.3390/ma11020322 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wu, Yanju
Zhou, Anxing
Yang, Huimin
Wang, Fei
Lu, Kui
3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil
title 3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil
title_full 3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil
title_fullStr 3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil
title_full_unstemmed 3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil
title_short 3D Graphene-Nitrogen Doped Carbon Nanotubes Network Modified Electrode as Sensing Materials for the Determination of Urapidil
title_sort 3d graphene-nitrogen doped carbon nanotubes network modified electrode as sensing materials for the determination of urapidil
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5849019/
https://www.ncbi.nlm.nih.gov/pubmed/29473881
http://dx.doi.org/10.3390/ma11020322
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